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Archiv-Übersicht     Angebot Nr. 13119

Angebotsdatum: 7. November 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Humanmedizin > Biochemie
Titel des Themas: The role of SPPL2 proteases in the homeostasis of SNARE proteins

Institut: Institut für Physiologische Chemie, TU Dresden
Adresse:
Prof. Bernd Schröder
Fiedlerstraße 42
01307 Dresden
Tel.: 0351-458-6450   Fax.:
Bundesland: Sachsen
Homepage: http:// https://tu-dresden.de/med/mf/pch/das-institut/arbeitsgruppen/berndschroeder/research
E-Mail Kontakt: mail

Beschreibung: Our group works on intramembrane proteolysis which links protein degradation with signal transduction and thus represents an important regulatory mechanism for cellular homeostasis. We are especially interested in the SPP/SPPL family of intramembrane proteases, which are mechanistically related to the γ-secretase complex that is involved in the pathology of Alzheimer disease. One member of this protease family, SPPL2a, we could identify as promising therapeutic target for the treatment of autoimmunity. Recently, human patients with SPPL2a deficiency were identified to lack certain dendritic cells and to be susceptible to mycobacterial infections.
We study SPP/SPPL in different functional and pathophysiological contexts.Therefore,different
projects with either a more pathophysiological or more mechanistic and cell biological focus are available. In one of the planned projects, we aim to characterize the impact of SPPL proteases on glucose homeostasis and metabolic regulation.
Methoden: We employ a large portfolio of biochemical, cell biological and molecular biological techniques to address cleavage by SPPL proteases and the functional consequences of these cleavage events. Beyond these cell-based approaches, we use mice as model organism in order to validate the (patho)-physiological relevance of the respective findings.
Anfangsdatum: 7. November 2018
Geschätzte Dauer: 3-4 Jahre
Bezahlung: TVL13 65% (Doktorarbeit)
Papers: - Schneppenheim et al. & Schröder (2013). The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain. J. Exp. Med., 210, 41-58.

- Mentrup, Loock, Fluhrer & Schröder (2017) Signal peptide peptidase and SPP-like proteases – possible therapeutic targets? Biochim. Biophys. Acta, 1864, 2169-2182.

- Mentrup, Fluhrer & Schröder (2017) Latest emerging functions of SPP/SPPL intramembrane proteases. Eur J Cell Biol, 96, 372-382.

- Kong, …., Schröder, ….. & Casanova (2018) Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol. 19, 973-985.
Sonstiges: We currently look for 2 PhD students.
Please apply electronically via:

https://www.uniklinikum-dresden.de/de/jobs-und-karriere/stellenangebote/wissenschaft/phd-student-in-biochemistry-cell-biology-f-m


In addition, Master students are always welcome!

If interested, please contact me via e-mail:
bernd.schroeder@tu-dresden.de

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