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Archiv-Übersicht     Angebot Nr. 13135

Angebotsdatum: 19. November 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Specificity of proteasome regulation during plant immunity

Institut: Universitaet Tuebingen , Zentrum fuer Molekularbiologie der Pflanzen
Adresse:
Dr. rer. nat. Suayib Uestuen
Auf der Morgenstelle 32
72076 Tuebingen
Tel.:    Fax.:
Bundesland: Baden-Württemberg
Homepage: http://theustunlab.com/
E-Mail Kontakt: mail

Beschreibung: PhD Position in Plant-microbe interaction

Project title: Specificity of proteasome regulation during plant immunity

Research: Our group at the ZMBP Tuebingen is interested in the role of proteolytic degradation pathways such as the proteasome and autophagy during plant immunity. Recently, we have identified that Pseudomonas syringae pv. tomato DC3000 (Pst) activates autophagy for proteasome degradation and enhanced pathogenicity (Üstün et al., 2018). We aim to study the specificity of proteasome regulation during plant-bacteria interactions by using a combination of cell biological, transcriptomics and biochemical methods. The work will include biochemical, cell biological, RNAseq, ChIP-Seq and genetic approaches using Arabidopsis and Pseudomonas syringae as the primary model organisms.

More information can be found on our lab homepage: http://theustunlab.com/

References:
Üstün S., Hafrén A., Liu Q., Marshall R., Minina E.A., Bozhkov P., Vierstra R., Hofius D. (2018) Bacteria exploit autophagy for proteasome degradation and enhanced virulence in plants. The Plant Cell Mar 2018, 30 (3) 668-685; DOI: 10.1105/tpc.17.00815
Üstün S., Sheikh A., Gimenez-Ibanez S., Jones A., Ntoukakis V., Börnke F. (2016) The proteasome acts as a hub for plant immunity and is targeted by Pseudomonas type-III effectors. Plant Physiology 172: 1941-1958

Requirements/Qualifications:
We are looking for a talented PhD student with proven expertise in cell and molecular biology, and Arabidopsis. Prior experiences with methods to study plant-microbe interactions are highly advantageous but not required. Excellent English communication skills as well as teamwork abilities are expected. A master’s degree in molecular biology, biochemistry or corresponding is required.

The position is available from January 01, 2019. Reviewing of applications will begin immediately and the position will remain open until a suitable candidate is found. Please send your application as a composite pdf-file in English (letter of motivation stating your research interests, CV, name and addresses of at least two referees) via email not later than 04.12.2018: suayib.uestuen@zmbp.uni-tuebingen.de

The ZMBP is a world‐class center for Plant Biology research and is situated in a brand-new and well-equipped building in the University of Tübingen science campus. The University of Tübingen is an equal opportunity employer and particularly welcomes applications from qualified women and individuals with disabilities. Formal employment procedures will be carried out by the central administration of the University of Tuebingen.
Methoden:
Anfangsdatum: 1. Januar 2019
Geschätzte Dauer: 3 Jahre
Bezahlung: Tarif TV-L
Papers: References:
Üstün S., Hafrén A., Liu Q., Marshall R., Minina E.A., Bozhkov P., Vierstra R., Hofius D. (2018) Bacteria exploit autophagy for proteasome degradation and enhanced virulence in plants. The Plant Cell Mar 2018, 30 (3) 668-685; DOI: 10.1105/tpc.17.00815
Üstün S., Sheikh A., Gimenez-Ibanez S., Jones A., Ntoukakis V., Börnke F. (2016) The proteasome acts as a hub for plant immunity and is targeted by Pseudomonas type-III effectors. Plant Physiology 172: 1941-1958
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