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Archiv-Übersicht     Angebot Nr. 13141

Angebotsdatum: 23. November 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Biologie
Titel des Themas: Post-Doctoral Fellow Position / PhD (E13 100%) about microRNAs in acute myeloid leukemia available

Institut: Division of Hematology and Oncology, Leipzig University
Adresse:
Prof. Gerhard Behre
Liebigstr. 22
04103 Leipzig
Tel.:    Fax.:
Bundesland: Sachsen
Homepage: http://https://www.uniklinikum-leipzig.de/einrichtungen/medizinische-klinik-1
E-Mail Kontakt: mail

Beschreibung: The group of Prof. Gerhard Behre (gerhard.behre@medizin.uni-leipzig.de) from the Division of Hematology and Oncology at Leipzig University is seeking for a highly motivated Post-Doctoral Fellow / PhD (E13 100%) that wants to join our research group. The focus of our work is on basic molecular and cellular investigations of leukemia biology, especially in the biology of small (and long) non-coding RNAs and their role in initiation and maintenance of acute myeloid leukemia (AML). For further information please read our recent publications (e.g. Wurm et al., Nature Comm. 2017) or contact us. In the planned project, we intend to study the suitability of specific microRNAs as therapeutic targets in AML. This includes basic in vitro investigations as well as verification in appropriate mouse models. After a initial period of training, the PhD should work independently and self-motivated, should particapte in writing research grants and scientific publications and presenting results at international research meetings.
Methoden: RIP (RNA immune precipitation)-sequencing, microRNA profiling and whole transcriptome profiling with next generation sequencing (NGS) with subsequent bioinformatics using Ingenuity Pathway Analysis (IPA) and functional analysis of microRNAs, e.g. with CRISPR/Cas9 technology and in vivo AML xeno graft mouse models (PDX-AML-cells in NSG mice)
Anfangsdatum: 1. März 2019
Geschätzte Dauer: 3 years
Bezahlung: E13 100%
Papers: 10 most important publications

1. Wurm AA, Zjablovskaja P, Kardosova M, Gerloff D, Bräuer-Hartmann D, Katzerke C, Hartmann JU, Benoukraf T., Fricke S, Hilger N, Müller AM, Bill M, Schwind S, Tenen DG, Niederwieser D, Alberich-Jorda M, Behre G. Disruption of the C/EBPα - miR-182 balance impairs granulocytic differentiation, Nat Commun. 2017 Jun 29;8(1):46.

2. Krakowsky RHE, Wurm AA, Gerloff D, Katzerke C, Braeuer-Hartmann D, Hartmann J, Wilke F, Thiede C, Müller-Tidow C, Niederwieser D, Behre G. miR-451a abrogates treatment resistance in FLT3-ITD-positive acute myeloid leukemia. Blood Cancer J 2018 Mar 21;8(3):36.

3. Hartmann J-U, Bräuer-Hartmann D, Kardosova M, Wurm AA, Wilke F, Schödel C, Gerloff D, Katzerke C, Krakowsky R, Namasu CY, Bill M, Schwind S, Müller-Tidow C, Niederwieser D, Alberich-Jorda M, Behre G. MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia. Cell Death Dis 2018 Jul 26;9(8):814.

4. Namasu CY, Katzerke C, Bräuer-Hartmann D, Wurm AA, Gerloff D, Hartmann J-U, Schwind S, Müller-Tidow C, Hilger N, Fricke S, Christopeit M, Niederwieser D, Behre G. ABR, a novel inducer of transcription factor C/EBPα, contributes to myeloid differentiation and is a favorable prognostic factor in acute myeloid leukemia. Oncotarget 2017, Oct 26;8(61):103626-103639

5. Pulikkan J, Tenen DG, Behre G. C/EBPα deregulation as a paradigm for leukemogenesis. Leukemia, 2017, Jul 19. doi: 10.1038/leu.2017.229. [Epub ahead of print]

6. Gerloff D, Grundler R, Wurm AA, Bräuer-Hartmann D, Katzerke C, Hartmann JU, Madan V, Müller-Tidow C, Duyster J, Tenen DG, Niederwieser D, Behre G. NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia. Leukemia. 2015 Mar;29(3):535-47.

7. Braeuer-Hartmann D, Hartmann J-U, Wurm AA, Gerloff D, Katzerke C, Verga Falzacappa M V, Pelicci PG, Mueller-Tidow C, Tenen DG, Niederwieser D and Behre G. PML/RARα -regulated microRNA 181b targets tumor suppressor RASSF1A in acute promyelocytic leukemia. Cancer Research 2015 Aug 15;75(16):3411-24.

8. Katzerke C, Madan V, Gerloff D, Bräuer-Hartmann D, Hartmann JU, Wurm AA, Müller-Tidow C, Schnittger S, Tenen DG, Niederwieser D, Behre G. Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia. BLOOD. 2013 Oct 3;122(14):2433-42.

9. Pulikkan JA, Peramangalam PS , Dengler V, Ho PA, Preudhomme C, Meshinchi S, Christopeit M, Nibourel O, Mueller-Tidow C, Bohlander SK, , Tenen DG, Behre G. C/EBPalpha regulated microRNA-34a targets E2F3 during granulopoiesis and is downregulated in AML with CEBPA mutations BLOOD. 2010 Dec 16;116(25):5638-49.

10. Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G. Aberrant regulation of a molecular network comprising C/EBPα, microRNA-223 and E2F1 in acute myeloid leukaemia BLOOD, 2010 Mar 4;115(9):1768-78.
Sonstiges: The PhD researcher should preferentially hold a PhD in biology, biochemistry or related subjects with a strong background in molecular biology, cell biology, bioinformatics and biochemistry. Experiences in animal handling is very benificial. Good spoken and written english skills are mandatory. The candiate should be able to work independently and to establish experimental strategies to answer biological questions.
For your application, please include:
(a) full curriculum vitae, information on years of experience in research and laboratory work and special skills, list of publications and/or congress participations (if available)
(b) name and contact information (email and telephone numbers) of the diploma/master supervisor as reference
(c) a summary of research interests and long term plans

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