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Archiv-Übersicht     Angebot Nr. 13145

Angebotsdatum: 26. November 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Epigenetic modifications in aging and hematopoietic differentiation

Institut: Stem Cell Biology and Cellular Engineering
Adresse:
Prof. Wolfgang Wagner
Pauwelsstrasse 20
52074 Aachen
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http://homepage: www.stemcellbiology.ukaachen.de
E-Mail Kontakt: mail

Beschreibung: The group „Stem Cell Biology and Cellular Engineering“ at RWTH Aachen Medical School is offering a position for a Ph.D. student (m/f).

Focus of this project is on epigenetic modifications in aging and hematopoietic differentiation. Aging is associated with highly reproducible DNA methylation changes, which can be used to estimate biological age. Furthermore, DNA methylation patterns can be used to estimate the composition of blood cells and to track hematopoietic malignancies. In this project, we want to further develop these biomarkers with new sequencing approaches. Furthermore, epigenetic writers and relevant proteins for chromatin structure will be modified (e.g. with CRISPR-Cas9n technology and overexpression) to determine their impact on the epigenetic makeup in aging and malignant transformation.
Methoden: All relevant techniques are established in the lab (including culture expansion, differentiation assays, flow cytometry, immunofluorescence and confocal microscopy, ddPCR, blotting techniques, genetic modifications, microarray platforms, pyrosequencing and deep sequencing technology.
Anfangsdatum: 1. Januar 2019
Geschätzte Dauer: 3-4 years
Bezahlung: Funding is available for at least three years (65%
Papers: https://scholar.google.de/citations?user=sp5F7kEAAAAJ&hl=de&oi=ao
Sonstiges: We are looking for a highly motivated and ambitious PhD student with a strong background in hematology, cell biology or epigenetics. Experience in bioinformatics would be appreciated. Willingness for teamwork, the ability to work independently, and excellent English language skills are a prerequisite.

We offer a highly interactive and well equipped environment in a team with international partners, a broad spectrum of methods, and a highly relevant topic.

The RWTH Aachen University is certified as a family-friendly university and offers a dual career program for partner hiring. We particularly welcome and encourage applications from women, disabled people and ethnic minority groups, recognizing they are underrepresented across RWTH Aachen University. The principles of fair and open competition apply and appointments will be made on merit.

Your application should include a cover letter which specifically emphasizes your interest in our work (preferably in English), CV, and copies of the most important certificates. For additional questions please contact Prof. Dr. Dr. Wolfgang Wagner. Your application should be send by Email until December 16th, 2018 (wwagner@ukaachen.de).

We are looking forward to your application!

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