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Archiv-Übersicht     Angebot Nr. 13174

Angebotsdatum: 6. Dezember 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Genetik
Titel des Themas: PhD: Development of epigenetic methods for blood counts based on DNA methylation

Institut: Universitätsklinikum RWTH Aachen, Stem Cell Biology
Prof. Wolfgang Wagner
Pauwelsstrasse 20
52074 Aachen
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http://homepage: www.stemcellbiology.ukaachen.de
E-Mail Kontakt: mail

Beschreibung: Focus of this project is the development of epigenetic methods for blood counts based on DNA methylation data. The analysis of the composition of cell types in blood is one of the most frequently used diagnostic test. We have established a simple method to determine blood counts based on DNA methylation at specific sites in the genome (Frobel et al., Clin Chem. 2018. doi: 10.1373/clinchem.2017.279935). This method shall now be further developed and validated. DNA methylation profiles will be analyzed in hematopoietic subsets with different sequencing approaches. This data needs to be evaluated and compiled into deconvolution algorithms. This project will be funded by a VIP+ project (BMBF) with the perspective to generate an in vitro diagnostic tool that may be further marketed.
Methoden: Nanopore sequencing, barcoded bisulfite amplicon sequencing, ddPCR, pyrosequencing, data analysis and maschine learning approaches etc.
Anfangsdatum: 6. Dezember 2018
Geschätzte Dauer: Three years
Bezahlung: Funding is available for at least three years (65%
Papers: https://www.researchgate.net/profile/Wolfgang_Wagner4

Sonstiges: We are looking for a highly motivated and ambitious PhD student with a strong background in bioinformatics and epigenetics. Experience in wet lab biology would be advantageous. Willingness for teamwork, the ability to work independently, and excellent English language skills are a prerequisite.

We offer a highly interactive and well equipped environment in a team with international partners, a broad spectrum of methods, and a highly relevant topic.

Your application should include a cover letter which specifically emphasizes your interest in our work (preferably in English), CV, and copies of the most important certificates. For additional questions please contact Prof. Dr. Dr. Wolfgang Wagner. Your application should be send by Email (wwagner@ukaachen.de).

We are looking forward to your application!