|| We are looking for a highly motivated PhD student to work on the transcriptional and epigenetic events elicited as a result of endothelial-cardiomyocyte interactions during cardiovascular development and disease.
Dynamic interactions between endothelial cells and cardiomyocytes are crucial for cardiac morphogenesis, postnatal cardiac growth, contractile performance and rhythmicity. Cardiac endothelial cells release various factors that drive cardiomyocyte proliferation, survival and contraction. Similarly, signaling from myocardial to endothelial cells is required for cardiac development and function. At a molecular level, these dynamic cell interactions induce signaling cascades, which converge to induce transcriptional and epigenetic programming that directs cardiomyocyte behavior and regulates cardiac function. Our aim is to decipher the transcriptional and epigenetic events occurring as a result of endothelial-cardiomyocyte communications.
We use a wide range of biochemical, molecular/cell biological, embryological and transgenic techniques to study cardiovascular development and disease both in vitro (cell culture) and in vivo in mouse and zebrafish.
The applicant should possess a solid background in molecular and cell biology; specific experience in embryonic development, stem cell biology and/or epigenetics will be an advantage.
The successful candidates will work in the group of Prof. Dr. Gergana Dobreva at the the Medical Faculty Mannheim, University of Heidelberg, which provide excellent research facilities, as well as a friendly and dynamic working environment.