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Archiv-Übersicht     Angebot Nr. 13190

Angebotsdatum: 13. Dezember 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Sonstiges
Titel des Themas: “The role of activins and MCP-1/CCL2 in the development of fibrotic response during chronic testicular inflammation in mice”

Institut: Institut für Anatomie und Zellbiologie
Frau Pia Jürgens
Aulweg 123
35392 Gießen
Tel.:    Fax.:
Bundesland: Hessen
Homepage: http://www.uni-giessen.de/IRTG-monash-giessen
E-Mail Kontakt: mail

Beschreibung: Collaborative project P7 of the International Research Training Group "Molecular Pathogenesis of Male Reproductive Disorders" between Monash University Melbourne (AUS) and Justus Liebig University Giessen (GER). (More information: www.uni-giessen.de/IRTG-monash-giessen)

Project description:
Infection and inflammation of the genital tract are amongst the most important aetiologies of male infertility. Experimental autoimmune epididymo-orchitis (EAO) is a model of testicular inflammation mimicking pathology observed in some cases of human male idiopathic spermatogenic disturbances that can lead to infertility. EAO is characterized by production of testicular auto-antibodies, elevated levels of inflammatory mediators, including TNF, monocyte chemoattractant protein-1 (MCP-1) and activin A, interstitial infiltration by immune cells, severe lesions of the seminiferous tubules and development of fibrosis and germ cell apoptosis.
The PhD candidate will investigate the contribution of activins and MCP-1 in spermatogenic damage and fibrotic response during testicular inflammation in an experimental model of autoimmune orchitis in mouse. Moreover, experimental strategies to dampen testicular inflammation and development of fibrotic remodelling will be in a focus of investigation. The methodological spectrum includes immunological (e.g. ELISA, immunohistochemistry, flow cytometry), biochemical (e.g. immunoblot), cell culture (isolation of primary cell lines) and molecular biology (e.g. qRT-PCR) techniques.

Scientific environment:
The unique collaboration of this IRTG comprises a large team of international experts in male reproductive medicine in which students are co-supervised by researchers in both universities. The candidates get specialized postgraduate training and carry out research in the laboratories at both sites with the possibility to achieve a Joint Award (min. 12 months abroad).
The student works on one of the 11 collaborative projects of the IRTG, each tackling different aspects of male reproductive health issues and the biology that underpins testis function.

Our Team
Home base: Research group “Reproductive Biology”, Institute of Anatomy and Cell Biology, Justus Liebig University Giessen (JLU), Germany (2 years) and
Host institution: Centre for Reproductive Health, Hudson Institute of Medical Research, affiliated with Monash University, Melbourne (Clayton), Australia (1 year)

Our group at JLU has a long-standing interest in deciphering pathological mechanisms leading to the disruption of testicular immune privilege and subsequent infertility. We are interested in the developing of new diagnostic markers and therapeutical strategies in the treatment of testicular inflammation. We offer a young, dynamic and international team of 12-15 people and well equipped modern laboratories with excellent training opportunities. Our research team is very supportive, interactive and intellectually ambitious, and we welcome the opportunity to work with colleagues who share our enthusiasm. The student will join an intensive supervision as well as a space for the development of own ideas.
Methoden: The methodological spectrum includes immunological (e.g. ELISA, immunohistochemistry, flow cytometry), biochemical (e.g. immunoblot), cell culture (isolation of primary cell lines) and molecular biology (e.g. qRT-PCR) techniques.
Anfangsdatum: 13. Dezember 2018
Geschätzte Dauer: 3 Years
Bezahlung: E13, TV-H (65%)
Sonstiges: Expected skills
You have a high-ranked degree in science, cell biology or molecular biology, biochemistry, immunology or related (top 20 % of the year). Your eligibility is not only reflected by your marks, but you demonstrate outstanding interest in scientific issues and show excellent analytical skills. You can document your scientific suitability by your own scientific work and e.g. voluntary internships and lab rotations. You are familiar with basic histological and molecular techniques. Knowledge of more sophisticated methods) is of advantage. Established experience in the field of animal models is highly desirable.
You are keen on learning about new methodologies. You are a team worker but also able to develop your own ideas independently and find solutions for open questions and challenges. You should be familiar with basics of data analysis, literature research and scientific writing.

Offering an international training scheme designed to develop and advance future leaders in men’s health research, IRTG is looking for highly motivated, committed and persistent candidates showing excellent qualifications with a good command of English (written and spoken) and of standard software being prepared to spend a year in Australia.

How to apply
If you meet the requirements and want to put in an application, please submit the following documents:
■ A Letter of Intent in English that includes your
■ Academic aptitude
■ Academic and professional interest
■ Specific interest in the chosen project
■ Motivation to join the IRTG
■ A Curriculum vitae (CV) including a recent photograph
■ Certified copies (in English or German) of all certificates awarding relevant degrees (Bachelor's and Master's or equivalent giving direct admission to doctoral studies)
■ Certified copies (in English or German) of the related transcripts of records, showing the studied subjects and the grades or points earned; information on your ranking should also be included.
■ Proof of proficiency in English, i.e.
■ TOEFL (95 points internet based) or
■ IELTS (6.5, no band less than 6.0)
■ CEFR level B2/C1
■ Two letters of recommendation from different professors/ supervisors who are familiar with your previous academic work

Please submit your application in one single pdf-file via email to: monika.fijak@anatomie.med.uni-giessen.de