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Archiv-Übersicht     Angebot Nr. 13206

Angebotsdatum: 21. Dezember 2018
Art der Stelle: Diplomarbeit
Fachgebiet: Humanmedizin > Immunologie
Titel des Themas: Targeted Delivery to Immune cells

Institut: Max Planck Institut für Kolloid- und Grenzflächenforschung
Dr. rer. nat. Christoph Rademacher
Am Mühlenberg 1
14476 Potsdam
Tel.:    Fax.:
Bundesland: Brandenburg
Homepage: http://www.mpikg.mpg.de/StructuralGlycobiology
E-Mail Kontakt: mail

Beschreibung: The “Structural Glycobiology” group at the Max Planck Institute of Colloids and Interfaces in Potsdam is looking for motivated and ambitious students for internships up to three months or Master Thesis work with a background in Biochemistry, Biology, Chemistry or related subjects.
Our motivation: During cancer progression, a tumor promotes an immunosuppressive environment preventing an efficient anti-tumor response of the immune system. To reactivate this response and overcome the immunosuppression, dendritic cells have been identified as attractive cellular targets that upon uptake of tumor antigens foster a stimulation of cytotoxic T cells. Thereby these cells promote killing of the tumor. This concept is a promising route in cancer immunotherapy. However, the current application of antibodies for the targeted delivery bears several drawbacks (e.g. immunogenicity and cargo release) and to overcome these, the Structural Glycobiology team explores the concept of ligand-based delivery vehicles. Briefly, liposomes are decorated with low molecular weight drug-like molecules that specifically bind to C-type lectins on dendritic cells enabling the uptake of such nanoparticle delivery devices. Recently, we could show specific targeting of Langerhans cells from human skin.
Our Approach: We apply modern methods from biophysics such as nuclear magnetic resonance and surface plasmon resonance to identify small molecules ligands for immune cell receptors. At the same time, we make use of a large repertoire of cell-based assays in ranging from high-dimensional flow cytometry, confocal microscopy and single particle tracking to follow the fate of our targeted delivery vehicles and study the immunological consequences.
Our research environment: Located 30 min outside of Berlin, the “Structural Glycobiology” group is embedded in the Department of Biomolecular Systems, with access to state-of-the-art research facilities. A comprehensive repertoire of instruments (700 MHz, 600 MHz, and 2x400 MHz NMR, SPR, ITC, 384well automated FACS (3 laser), qPCR, Leica Sp8 confocal microscope, STED microscope etc.) stands alongside with high-profile collaborators in a fruitful research spectrum covering synthetic organic chemistry, biochemistry, glycobiology, nanotechnology, immunology and biophysics.
Methoden: Modern methods from biophysics such as nuclear magnetic resonance and surface plasmon resonance and cell-based assays ranging from high-dimensional flow cytometry, confocal microscopy and single particle tracking.
Anfangsdatum: 21. Dezember 2018
Geschätzte Dauer: 3 to 6 month
Bezahlung: none
Papers: Aretz J. et al. J Am Chem Soc, 2018, just accepted.
Wamhoff EC. et al. BioRxiv 2018, pre-print.
Aretz J. et al. Angew Chem Int Ed Engl., 2017, 56, 1-6
Hanske J. et al. J Am Chem Soc, 2016, 136, 12176-86.