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Archiv-Übersicht     Angebot Nr. 13211

Angebotsdatum: 27. Dezember 2018
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Scientist (f/m) for “Base Correction“ in Pluripotent Cells

Institut: Clinic for Neurosurgery, Medical Faculty Heinrich-Heine University Dusseldorf
Adresse:
Dr. rer. nat. Kahlert
Moorenstrasse 5
40225 Düsseldorf
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage:
E-Mail Kontakt: mail

Beschreibung: In vitro disease models represent the earliest stage of wet-lab-based preclinical research. In oncology, traditional disease models comprise patient-derived systems. However, recent research has challenged the suitability of such classical models for chemo therapy prediction studies. Alternative donor-derived in vitro disease models with elevated genetic circumscription are considered to putatively be more suitable for physiological relevant target discovery and therapy testing in high-throughput.

The Department of Preclinical Research at the Neurosurgical Clinical of the Heinrich-Heine University, Düsseldorf, Germany is looking for a motivated candidate to fill a position to develop targeted transformation strategies in pluripotent cells (particularly human induced pluripotent stem cells as well as human fetal-derived neural stem cells, summarized as pluripotent cells, PC). Specifically, the establishment of efficient base correction assays to introduce point mutations as physiological relevant onco-disease models is envisioned. The candidate will be guided on the technology level by international and national leading experts in base corrector technology including on-site visits, regular data discussion etc. The ultimate goal is to validate those based-corrected cell systems in terms of acquisition of pathophysiological relevant tumorigenicity as well as chemo therapy resistance profiles compared to classical disease models as well as to overexpression/gene KD-mediated PC-based disease models.

The position is funded through the High-tech Strategy of the Federal Ministry of Education and Research (BMBF, https://www.validierungsfoerderung.de/validierungsprojekte/discover ) and thereafter through alternative sources (total of 3 years minimum, starting as of Jan 2019). Please send the concise application documents (incl. one scientific reference) as one PDF file per e-mail to ulf.kahlert@med.uni-duesseldorf.de . The candidate will be embedded in an interdisciplinary research team consisting of researches with medical and natural science background (see homepage of the clinic).

Selected references:
https://www.ncbi.nlm.nih.gov/pubmed/30089904
https://www.ncbi.nlm.nih.gov/pubmed/28991255
https://www.ncbi.nlm.nih.gov/pubmed/28529064
https://www.ncbi.nlm.nih.gov/pubmed/29849122
Methoden:
Anfangsdatum: 27. Dezember 2018
Geschätzte Dauer: 3 Jahre
Bezahlung: TV-L E11-13, part-time
Papers:
Sonstiges:

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