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Archiv-Übersicht     Angebot Nr. 13212

Angebotsdatum: 28. Dezember 2018
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: PhD: Epigenetic modifications in aging and hematopoietic differentiation

Institut: RWTH Aachen Medical School, Stem Cell Biology and Cellular Engineering
Prof. Wolfgang Wagner
Pauwelsstrasse 20
52074 Aachen
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http://www.stemcellbiology.ukaachen.de
E-Mail Kontakt: mail

Beschreibung: Focus of this project is on epigenetic modifications in aging and hematopoietic differentiation. Aging is associated with highly reproducible DNA methylation changes, which can be used to estimate biological age. Furthermore, DNA methylation patterns can be used to estimate the composition of blood cell types and to track hematopoietic malignancies. In this project, we want to develop these biomarkers further with new sequencing approaches. Furthermore, epigenetic writers and relevant proteins for chromatin structure will be modified (e.g. with CRISPR-Cas9n technology and overexpression) to determine their impact on the epigenetic makeup in aging and malignant transformation.
Methoden: All relevant techniques are established in the lab - including culture expansion, differentiation assays, flow cytometry, immunofluorescence and confocal microscopy, ddPCR, blotting techniques, genetic modifications, microarray platforms, pyrosequencing and deep sequencing technology.
Anfangsdatum: 1. März 2019
Geschätzte Dauer: Three years
Bezahlung: Funding is available for at least three years (65%
Papers: https://www.researchgate.net/profile/Wolfgang_Wagner4

Sonstiges: We are looking for a highly motivated and ambitious PhD student with a strong background in cell biology or epigenetics. Experience in bioinformatics would be appreciated. Willingness for teamwork, the ability to work independently, and excellent English language skills are a prerequisite.

We offer a highly interactive and well equipped environment in a team with international partners, a broad spectrum of methods, and a highly relevant topic.

Your application should include a cover letter which specifically emphasizes your interest in our work (preferably in English), CV, and copies of the most important certificates. For additional questions please contact Prof. Dr. Dr. Wolfgang Wagner. Your application should be send by Email (wwagner@ukaachen.de).

We are looking forward to your application!