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Archiv-Übersicht     Angebot Nr. 13218

Angebotsdatum: 7. Januar 2019
Art der Stelle: Diplomarbeit
Fachgebiet: Physik > Angewandte Physik
Titel des Themas: Radio Frequency Resonator (RF Coil) Design for Functional 17O-MRI of Kidney Transplants

Institut: Uniklinik Freiburg
Prof. Michael Bock
Killianstr. 5a
79106 Freiburg
Tel.: +49 761 270 94140   Fax.:
Bundesland: Baden-Württemberg
Homepage: http://https://www.uniklinik-freiburg.de/mr-en/research-groups/exprad.html
E-Mail Kontakt: mail

Beschreibung: Most organ transplants are renal transplants. Survival rates decrease drastically with time after transplantation. One reason for post-transplantation complications is the insufficient functional characterization of the transplanted kidney. Besides perfusion and renal filtration, an important renal function parameter is tissue oxygenation. A direct method to assess the metabolic rate of oxygen consumption is dynamic 17O-MRI, which has been extensively used for metabolic measurements in the brain. Previously, we proposed a 17O-MR measurement protocol to spatially assess renal metabolic rates of oxygen consumption in donor organs.
In this master’s project, an RF coil array for 17O MRI will be designed and constructed. The coil fits tightly to a renal system where the kidney is perfused with an oxygenated solution containing red blood cells. The design approach is to maximize the SNR by increasing the filling ratio. A transmit volume coil will also be configured to enable transmit-only operation. An interface circuit for the RF coils has already been designed and it will be constructed on a printed circuit board and integrated to the coil array. Finally, the performance of the setup will be evaluated on a 3 T clinical MRI system.
Methoden: The successful candidate should have an interest and initial experience/background in:
• Electromagnetics
• Radio frequency electronics
• Soldering
We offer:
• An interdisciplinary dynamic research environment
• State-of-the-art lab equipment
• Improving RF circuit design skills
• An introduction to electromagnetic simulation tools
• Possible extension of the project towards a PhD study
The starting date is negotiable.
Anfangsdatum: 7. Januar 2019
Geschätzte Dauer: 12 months
Papers: Kurzhunov D, Borowiak R, Reisert M, Özen AC, Bock M. Direct estimation of (17)O MR images (DIESIS) for quantification of oxygen metabolism in the human brain with partial volume correction. Magn Reson Med. 2018 Dec;80(6):2717-2725. doi:

Kurzhunov D, Borowiak R, Reisert M, Joachim Krafft A, Caglar Özen A, Bock M. 3D CMRO(2) mapping in human brain with direct (17)O MRI: Comparison of
conventional and proton-constrained reconstructions. Neuroimage. 2017 Jul 15;155:612-624. doi: 10.1016/j.neuroimage.2017.05.029.

Borowiak R, Reichardt W, Kurzhunov D, Schuch C, Leupold J, Krafft AJ, Reisert M, Lange T, Fischer E, Bock M. Initial investigation of glucose
metabolism in mouse brain using enriched (17) O-glucose and dynamic (17) O-MRS. NMR Biomed. 2017 Aug;30(8). doi: 10.1002/nbm.3724.

Kurzhunov D, Borowiak R, Hass H, Wagner P, Krafft AJ, Timmer J, Bock M. Quantification of oxygen metabolic rates in Human brain with dynamic (17)O MRI: Profile likelihood analysis. Magn Reson Med. 2017 Sep;78(3):1157-1167. doi: 10.1002/mrm.26476.

Borowiak R, Groebner J, Haas M, Hennig J, Bock M. Direct cerebral and cardiac 17O-MRI at 3 Tesla: initial results at natural abundance. MAGMA. 2014 Feb;27(1):95-9.

Hoffmann SH, Begovatz P, Nagel AM, Umathum R, Schommer K, Bachert P, Bock M. A measurement setup for direct 17O MRI at 7 T. Magn Reson Med. 2011 Oct;66(4):1109-15. doi: 10.1002/mrm.22871.
Sonstiges: For further information please contact:
Dr. Ali Caglar Özen (ali.oezen@uniklinik-freiburg.de)