Zur Startseite von DrArbeit.de,
der deutschlandweiten Stellenbörse für Diplomarbeiten und Doktorarbeiten


Lupe2

Archiv - Stellenangebot

 

Dies ist ein Angebot aus der Datenbank von DrArbeit.de

Um die Datenbank komfortabel nach weiteren Angeboten durchsuchen zu können, klicken Sie einfach oben oder hier.

 
Archiv-Übersicht     Angebot Nr. 13231

Angebotsdatum: 11. Januar 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Structural and biochemical analysis of inositol pyrophosphate signaling pathways

Institut: Universitaet Genf / Department for Botany and Plant Biology / Structural Plant Biology Laboratory
Adresse:
Prof. Michael Hothorn
Science III, 30 Quai E Ansermet
1211 Geneva
Tel.: 0041223793013   Fax.:
Bundesland:
Homepage: http://structplantbio.org
E-Mail Kontakt: mail

Beschreibung: Applications are invited for a PhD position, starting any time in 2019, in the group Prof. Michael Hothorn at University of Geneva (http://structplantbio.org). The lab combines structural biology (X-ray protein crystallography, cryo electron microscopy) and quantitative biochemistry with genetics and cell biology to dissect novel signal transduction pathways required for plant growth and development. The successful candidate will investigate how inositol pyrophosphate signaling molecules involved in nutrient signaling interact with different plant signaling proteins and protein complexes. She/he will use state-of-the art molecular biology, protein biochemistry and structural biology techniques to characterize these interactions in molecular detail.

The candidate should have a first class degree in biochemistry or closely related subject and ideally prior experience in molecular biology and in protein biochemistry. A basic knowledge of protein expression and purification, quantitative biochemistry, and in protein crystallography or cryoEM would be highly appreciated.

Applications should be sent Prof. Michael Hothorn (michael.hothorn@unige.ch) as a single PDF document, containing a 2 page CV (including details on the final grade or the expected grades) and a motivational statement of up to 2 pages. Applicants should also include contact details of 2-3 academic referees.

Informal inquiries can be addressed by email to Prof. Michael Hothorn (michael.hothorn@unige.ch). More information can be found here: http://structplantbio.org
Methoden: Proteinexpression und Reinigung, Kalorimetrie, SPR, Proteinkristallographie, Elektronenmikroskopie
Anfangsdatum: 1. Mai 2019
Geschätzte Dauer: 3 bis maximal 5 Jahre
Bezahlung: Doktorandenvertrag mit Sozialversicherung ca. 45,0
Papers: Zhu J, Lau K, Harmel RK, Puschmann R, Broger L, Dutta AK, Jessen HJ, Hothorn LA, Fiedler D, Hothorn M (2019) Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis. bioRxiv doi: https://doi.org/10.1101/467076
Hohmann U, Nicolet J, Moretti A, Hothorn LA, Hothorn M (2018) The SERK3 elongated allele defines a role for BIR ectodomains in brassinosteroid signalling. Nature Plants 4:345-351 doi: 10.1038/s41477-018-0150-9
Hohmann U, Santiago J, Nicolet J, Olsson V, Spiga FM, Hothorn LA, Butenko MA, Hothorn M (2018) Mechanistic basis for the activation of plant membrane receptor kinases by SERK-family coreceptors. PNAS 115(13):3488-3493
Wild R†, Gerasimaite R†, Jung JY†, Truffault V, Pavlovic I, Schmidt A, Saiardi A, Jessen HJ, Poirier Y*, Hothorn M*, Mayer A* (2016) Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains. Science 352(6288):986-90
Sonstiges:

Archiv-Übersicht