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Archiv-Übersicht     Angebot Nr. 13262

Angebotsdatum: 29. Januar 2019
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: PhD position in Epigenetic regulation of Cardiovascular Development and Disease

Institut: Medical Faculty Mannheim/University of Heidelberg
Adresse:
Frau Gergana Dobreva
Ludolf-Krehl-Str. 7-11
68167 Mannheim
Tel.:    Fax.:
Bundesland: Baden-Württemberg
Homepage:
E-Mail Kontakt: mail

Beschreibung: We are looking for a highly motivated PhD student to work on the transcriptional and epigenetic events elicited as a result of endothelial-cardiomyocyte interactions during cardiovascular development and disease.
Dynamic interactions between endothelial cells and cardiomyocytes are crucial for cardiac morphogenesis, postnatal cardiac growth, contractile performance and rhythmicity. Cardiac endothelial cells release various factors that drive cardiomyocyte proliferation, survival and contraction. Similarly, signaling from myocardial to endothelial cells is required for cardiac development and function. At a molecular level, these dynamic cell interactions induce signaling cascades, which converge to induce transcriptional and epigenetic programming that directs cardiomyocyte behavior and regulates cardiac function. Our aim is to decipher the transcriptional and epigenetic events occurring as a result of endothelial-cardiomyocyte communications.

The successful candidates will work in the group of Prof. Dr. Gergana Dobreva at the the Medical Faculty Mannheim, University of Heidelberg, which provide excellent research facilities, as well as a friendly and dynamic working environment.
Methoden: We use a wide range of biochemical, molecular/cell biological, embryological and transgenic techniques to study cardiovascular development and disease both in vitro (cell culture) and in vivo in mouse and zebrafish.

The applicant should possess a solid background in molecular and cell biology; specific experience in embryonic development, stem cell biology and/or epigenetics will be an advantage.
Anfangsdatum: 29. Januar 2019
Geschätzte Dauer: 3-4 years
Bezahlung:
Papers: Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G. “The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.” Cell Stem Cell 2015, 17(3):287-99

Cheedipudi S, Genolet O, Dobreva G. “Epigenetic inheritance of cell fates during embryonic development.” Front Genet 2014, 5:19.

Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM, Dimmeler S. “Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells.” Circ Res 2013, 113(7):856-62

Witzel H, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G. “The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity” Dev Cell 2012, 23(1):58-70
Sonstiges:

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