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Archiv-Übersicht     Angebot Nr. 13270

Angebotsdatum: 1. Februar 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Sonstiges
Titel des Themas: Plant bioactives as modulators of the ageing process in Drosophila melanogaster

Institut: Institute of Nutritional Sciences
Adresse:
Frau Wagenbach
Leihgesterner Weg 52
35392 Gießen
Tel.:    Fax.:
Bundesland: Hessen
Homepage: http://https://www.uni-giessen.de/fbz/zentren/ggl/overview/application
E-Mail Kontakt: mail

Beschreibung: In the present project, specific plant bioactives will be analyzed regarding their age-dependent effects especially in the context of the age-associated low-grade inflammation in the gut also known as “inflamm-ageing”. It will be investigated how these compounds affect different parameters associated with the ageing process including changes in the lifespan, transcriptomic changes as well as changes in the protein expression and the energy metabolism. As also the microbiome plays an essential role in the metabolization of these compounds the composition of the intestinal bacteria will be analyzed. Besides different wild-type fly lines also transgenic flies will be applied. The goal of the project is to identify plant-derived compounds that affect the lifespan of fruit flies and unravel the underlying mechanisms especially in the context of the process of inflamm-ageing.
Methoden: The PhD candidate should have successfully completed a scientific university course (MSc or Diploma degree) in Nutritional Sciences, Biology or another subject in the Life Science field. The candidate should have practical experience with molecular and cell biology related methods and ideally first experience in the handling of Drosophila melanogaster.Knowledge in the field of molecular biology and/or genetics would be an advantage. A high interest in scientific questions and good English language skills are mandatory.
Anfangsdatum: 15. April 2019
Geschätzte Dauer: 3 years
Bezahlung: Doctoral position (50%)
Papers:
Sonstiges: Please apply via our application portal.

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