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Archiv-Übersicht     Angebot Nr. 13352

Angebotsdatum: 15. März 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Chemie > Biochemie
Titel des Themas: Identification of intracellular targets of pro- and anti-inflammatory substances from plants

Institut: Institut für Laboratoriumsmedizin, Klinische Chemie und Pathobiochemie
Prof. Hendrik Fuchs
Augustenburger Platz 1
13353 Berlin
Tel.: 030 450 569173   Fax.:
Bundesland: Berlin
Homepage: http://https://ilp.charite.de/forschung/ag_fuchs/jobs/
E-Mail Kontakt: mail

Beschreibung: Within the framework of a project granted by the Deutsche Forschungsgemeinschaft, we intend to investigate the biological effects of anti- and pro-inflammatory substances on the molecular level in eukaryotic cell culture experiments. The project specifically involves the identification of cellular targets addressed by secondary plant metabolites. The project offers the chance to work in a multi-disciplinary team with numerous international collaborations in one of the best medical universities in Germany. Moreover, the location of the lab is in the heart of Berlin, which is a historical city with vibrancy and the place to be in for science.
Methoden: – purification of glycosides from selected plant raw material by preparative HPLC and other methods
– quality control of purified and purchasable glycosides by LC-MS, MALDI and other methods
– determination of pro- and anti-inflammatory effects of such glycosides in human and mouse cell lines by different methods including reporter gene assays, Western blot and real-time PCR
– cellular target identification by a variety of methods including dye-labeling, affinity chromatography, recovery after sub-cellular fractionation, inhibitor studies, measuring membrane integrity and investigation of biological pathways
– structure analysis by MALDI and NMR in cooperation with the Leibniz Institute of Plant Biochemistry
– determination of structure-function relationships suitable to define a pharmacophore
– eukaryotic cell culture
– publication of results in high-quality peer reviewed journals
– supervision of Bachelor and Master students working in the same project
occasional travelling to project partners
– attending scientific meetings and presenting results
Anfangsdatum: 15. März 2019
Geschätzte Dauer: 3 Jahre
Bezahlung: E13 (65%)
Sonstiges: The only officially valid advertisement is the advertisement on https://www.charite.de/karriere/stellenboerse/



hendrik.fuchs@charite.de as a single PDF file of max. 5 MB including the application form available at https://ilp.charite.de/forschung/ag_fuchs/