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Archiv-Übersicht     Angebot Nr. 13415

Angebotsdatum: 10. Mai 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Biologie
Titel des Themas: PhD student position about RNA biology in acute myeloid leukemia

Institut: Medical Clinic 1 - Hematology at Leipzig University, Germany
Prof. Gerhard Behre
Liebigstr. 22
04103 Leipzig
Tel.:    Fax.:
Bundesland: Sachsen
E-Mail Kontakt: mail

Beschreibung: PhD student position (biologischer Doktorand, cand. Dr. rer. nat.)
about RNA biology in acute myeloid leukemia
in the research group Behre from Medical Clinic 1 – Hematology
at Leipzig University, Germany available
Methoden: A PhD student position (biologischer Doktorand, cand. Dr. rer. nat.) is available in the research group Behre from the Medical Clinic 1 - Hematology at Leipzig University for applicants interested in gene regulation and epigenetics in acute myeloid leukemia (AML) and stem cell biology. The main focus of the laboratory is the role of RNA in gene / epigenetic regulation, particularly in hematopoiesis and leukemias. Examples are regulation of microRNAs by key transcription factors such as C/EBPalpha in myeloid differentiation and acute myeloid leukemia (Wurm et al., Nature Comm. 2017: Disruption of the C/EBPalpha - miR-182 balance impairs granulocytic differentiation), translational usage of microRNAs to overcome treatment resistance in AML (Krakowsky et al., Blood Cancer J 2018: miR-451a abrogates treatment resistance in FLT3-ITD-positive acute myeloid leukemia), or microRNAs targeting transcription factors in the pathogenesis of AML (Gerloff et al., Leukemia 2014: NF-kappa B/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia). Please also have a look at our further recent publications: Katzerke, Blood 2013; Hartmann, Cell Death Dis 2018; Namasu, Oncotarget 2017; Pulikkan, Leukemia 2017; Braeuer-Hartmann, Cancer Research 2015; Pulikkan JA, Peramangalam PS, Blood 2010; Pulikkan, Dengler, Blood 2010; Pulikkan, Leukemia 2010.
The focus of our work is on basic molecular and cellular investigations of leukemia biology, especially in the biology of small and long non-coding (lnc) RNAs and their role in initiation and maintenance of AML, and the translation of this knowledge into novel therapeutic concepts for AML. These projects include basic in vitro investigations as well as verification in appropriate mouse models. In the planned projects, we intend to study the suitability of specific microRNAs and lncRNAs as therapeutic targets in AML, or as translational tools to overcome therapy resistance in AML. Furthermore, we aim to use RNA expression profiles to guide AML treatment decisions. Methods used in the lab include microRNA, lncRNA, and whole transcriptome profiling with next generation sequencing (NGS) with subsequent bioinformatics and mechanistic and functional analysis of microRNAs, e.g. with CRISPR/Cas9 technology and in vivo AML xenograft mouse models or inducible C/EBPalpha knock-out mice. Other projects involving gene regulation and leukemia are ongoing as well.
Anfangsdatum: 1. Juli 2019
Geschätzte Dauer: 3 years
Bezahlung: E13 (65%)
Sonstiges: PhD student candidates must have a proven track record in research and laboratory work. Ability to communicate in written and spoken English is required. Experiences in molecular biology and biochemistry including molecular cloning, next generation sequencing (NGS), bioinformatics, and animal handling is necessary. For your email application to Prof. Dr. med. Gerhard Behre (gerhard.behre@medizin.uni-leipzig.de) please include: 1) full curriculum vitae, publication list, information on years of experience in research and laboratory work including the methods you already know how to do perfectly; 2) names and contact information (email and telephone numbers) of 3 references; 3) a summary of research interests and long term plans; 4) two half page proposals of which two projects the applicant might want to do in the laboratory during 3 years. Only shortlisted applicants will be notified.