Analysis of an interplay between acute stress and traumatic brain injury in mice
Prof. Bernd Knöll
Traumatic brain injury (TBI) caused by an external mechanical impact results in transient or persisting cognitive and physical impairments. This project analyses an interplay between TBI and acute stress (AS) exposure. We will address the question how a previous stress exposure affects recovery after trauma and vice versa how a previous TBI affects acute stress coping behaviour. Experimental techniques involve in vivo mouse models of TBI and AS exposure, histology, biochemistry, gene expression and behavioural tests. From a molecular point of view we will analyse whether neuroprotective gene expression programs exerted by the transcription factors SRF (serum response factor) or ATF3 (activating transcription factor 3) are involved in this interplay.