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Archiv-Übersicht     Angebot Nr. 13462

Angebotsdatum: 12. Juni 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Chemie > Biochemie
Titel des Themas: PhD position (Medical Biochemistry & Molecular Biology): Biogenesis and Function of Lipid Droplets

Institut: Medical Biochemistry & Molecular Biology; Center for Molecular Signaling (PZMS)
Adresse:
Prof. Bianca Schrul
Kirrberger Str. 100
66421 Homburg
Tel.:    Fax.:
Bundesland:
Homepage: http://www.pzms.uni-saarland.de/index.php/junior-prof-bianca-schrul
E-Mail Kontakt: mail

Beschreibung: Our research group is interested in the biogenesis and function of lipid droplets. These subcellular organelles dynamically balance the influx, storage and consumption of neutral lipids in nearly all cells of our body and are therefore central hubs in lipid metabolism. Lipid droplets are implicated in a range of human pathologies including hallmark diseases of our modern society such as obesity, diabetes, hepatic steatosis and cardiovascular disorders. However, the molecular mechanisms underlying lipid droplet biogenesis and function as well as pathologic aberrations in these processes remain largely unknown.

Projects in our lab address the following questions:

• What are the molecular mechanisms underlying protein targeting and insertion into the limiting membrane of lipid droplets?

• How is lipid droplet biogenesis from the endoplasmic reticulum membrane regulated?

• How do lipid droplets communicate with other lipid metabolizing organelles to adapt to metabolic changes?
Methoden: We employ a range of biochemical and cell biological techniques including in vitro reconstitution experiments, protein-interaction studies, organelle / protein isolations, CRISPR/Cas9 genome editing, RNA interference as well as advanced fluorescence and electron microscopy.
Anfangsdatum: 1. Juli 2019
Geschätzte Dauer: 3-4 years
Bezahlung: yes
Papers: Schrul B. and Kopito R.R.
Peroxin-Dependent Targeting of a Lipid Droplet-Destined Membrane Protein to ER Subdomains.
Nat Cell Biol. 2016 Jul;18(7):740-51, PMID: 27295553

Schrul B. and Schliebs W.
Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19.
Biol Chem. 2018 Jun 27;399(7):741-749, PMID: 29500918
Sonstiges: We are looking for a highly motivated scientist with the following qualifications:

- excellent Diploma / M.Sc. degree in Biochemistry, Molecular Biology, Molecular Medicine or a related discipline

- strong interest in basic Biochemical and Cell Biological research

- interest in working on an interdisciplinary project including wet-lab Biochemistry as well as Molecular Dynamics simulations would be beneficial

- excellent communication skills

- fluent English skills (oral and written)

- German language skills are desired



Benefits:

- Our young research team is integrated in an interdisciplinary and diverse research environment offering state-of-the-art technology and excellent scientific exchange.

- Further training opportunities are provided by Saarland University´s Graduate Centre GradUS.

- The position is immediately available for the duration of 3 years with the possibility of extension.

Please send your application including a short cover letter stating your research interests, a CV, degree certificates and contacts for two references via e-mail to Jun.-Prof. Dr. Bianca Schrul: bianca.schrul(at)uks.eu

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