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Archiv-Übersicht     Angebot Nr. 13537

Angebotsdatum: 22. Juli 2019
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: PhD position in Epigenetic regulation of Cardiovascular Development and Disease

Institut: Medical Faculty Mannheim/University of Heidelberg
Prof. Gergana Dobreva
Ludolf-Krehl-Str. 7-11
68167 Mannheim
Tel.:    Fax.:
Bundesland: Baden-Württemberg
E-Mail Kontakt: mail

Beschreibung: We are looking for a highly motivated PhD student to work on the transcriptional and epigenetic events elicited as a result of endothelial-cardiomyocyte interactions during cardiovascular development and disease.
Dynamic interactions between endothelial cells and cardiomyocytes are crucial for cardiac morphogenesis, postnatal cardiac growth, contractile performance and rhythmicity. Cardiac endothelial cells release various factors that drive cardiomyocyte proliferation, survival and contraction. Similarly, signaling from myocardial to endothelial cells is required for cardiac development and function. At a molecular level, these dynamic cell interactions induce signaling cascades, which converge to induce transcriptional and epigenetic programming that directs cardiomyocyte behavior and regulates cardiac function. Our aim is to decipher the transcriptional and epigenetic events occurring as a result of endothelial-cardiomyocyte communications.

Methoden: We use a wide range of biochemical, molecular/cell biological, embryological and transgenic techniques to study cardiovascular development and disease both in vitro (cell culture) and in vivo in mouse and zebrafish.
The applicant should possess a solid background in molecular and cell biology; specific experience in embryonic development, stem cell biology and/or epigenetics will be an advantage.
Anfangsdatum: 1. Oktober 2019
Geschätzte Dauer: 3-4 years
Papers: Gao R, Liang X, Cheedipudi S, Cordero J, Jiang X, Zhang Q, Caputo L, Günther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G. “Pioneering function of Isl1 in epigenetic control of cardiomyocyte cell fate.” Cell Research, 2019 Jun;29(6):486-501.
Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, Dobreva G, Zhou Y, Braun T. “Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice.” J Clin Invest. 2017 Jun 1;127(6):2235-2248.
Caputo L, Witzel HR, Kolovos P, Cheedipudi S, Looso M, Mylona A, van IJcken WF, Laugwitz KL, Evans SM, Braun T, Soler E, Grosveld F, Dobreva G. “The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.” Cell Stem Cell 2015, 17(3):287-99
Cheedipudi S, Genolet O, Dobreva G. “Epigenetic inheritance of cell fates during embryonic development.” Front Genet 2014, 5:19.
Witzel H, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G. “The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity” Dev Cell 2012, 23(1):58-70
Sonstiges: The successful candidates will work in the group of Prof. Dr. Gergana Dobreva at the the Medical Faculty Mannheim, University of Heidelberg, which provide excellent research facilities, as well as a friendly and dynamic working environment.
To apply, please send an application letter, CV and contact information of at least one referee to Prof. Dr. Gergana Dobreva (Gergana.Dobreva@medma.uni-heidelberg.de).