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Archiv-Übersicht     Angebot Nr. 13538

Angebotsdatum: 22. Juli 2019
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: PhD position in cancer epigenetics

Institut: Medical Faculty Mannheim/ University of Heidelberg
Prof. Gergana Dobreva
Ludolf-Krehl-Str. 7-11
68167 Mannheim
Tel.:    Fax.:
Bundesland: Baden-Württemberg
E-Mail Kontakt: mail

Beschreibung: We are looking for a highly motivated PhD student with strong interest in epigenetics and cell metabolism.
Metabolic reprogramming and alterations in nuclear architecture are hallmarks of cancer cells. Mounting evidence indicates that tumour metabolism is intricately interconnected with epigenetic reprogramming and nuclear reorganization in cancer cells. In a screen, we identified factors that play a fundamental role in lung cancer development and progression and in regulating cancer cell metabolism. The objective of the proposed research program is to elucidate on the one hand the mechanisms by which these factors regulate cancer cell metabolism and on the other hand how changes in cell metabolism affect chromatin association with the nuclear lamina, genome architecture and the epigenetic landscape. We expect that this work will contribute to better understanding the molecular players at the interface of cancer metabolism and epigenetics and may provide clues to novel approaches for tumour treatment.
Methoden: We use a wide range of biochemical, molecular/cell biological and transgenic techniques to study the crosstalk between epigenetics and metabolism both in cell culture and in vivo in mouse.
The applicant should possess a solid background in molecular and cell biology; specific experience in epigenetics and/ or studying cell metabolism will be an advantage.
Anfangsdatum: 1. Oktober 2019
Geschätzte Dauer: 3-4 years
Sonstiges: The successful candidates will work in the group of Prof. Dr. Gergana Dobreva at the the Medical Faculty Mannheim, University of Heidelberg, which provide excellent research facilities, as well as a friendly and dynamic working environment.

To apply, please send an application letter, CV and contact information of at least one referee to Prof. Dr. Gergana Dobreva (Gergana.Dobreva@medma.uni-heidelberg.de).