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Archiv-Übersicht     Angebot Nr. 13575

Angebotsdatum: 21. August 2019
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Entwicklungsbiologie
Titel des Themas: Specification of leg segments during arthropod development

Institut: Friedrich-Alexander-Universität, Erlangen
Prof. Martin Klingler
Staudtstr. 5, LS Entwicklungsbiologie
91058 Erlangen
Tel.: 049091318528065   Fax.:
Bundesland: Bayern
Homepage: http://klingler.tribolium.net
E-Mail Kontakt: mail

Beschreibung: In this project, the candidate will analyze a number of leg genes we identified during a genome-wide RNAi screen in the flour beetle Tribolium (Nat Commun 2015; 6:7822) which include previously unknown components of this developmental pathway. Since many appendage genes are conserved among arthropods and even vertebrates, this work also has implications for the evolution of morphological diversity within arthropods, and macroevolution of vertebrate and arthropod bauplans.
Methoden: We seek a highly motivated individual with enthusiasm for animal development and genetics, who is interested in solving a patterning problem of similar fundamental importance as body segmentation in vertebrates and arthropods. The candidate should have experience in basic molecular methods. A background in cell biology, biochemistry, developmental biology, evolutionary biology, advanced imaging or computer modelling would be an advantage.
Anfangsdatum: 21. August 2019
Geschätzte Dauer: 3 Jahre
Bezahlung: normale Doktorandenstelle (50%)
Papers: https://scholar.google.com/citations?user=rMc2ooYAAAAJ&hl=en
Sonstiges: Background: Although segmented legs are an important character of the largest animal phylum, the arthropods, it still is not fully known how these jointed legs are formed. Work in the fruit fly Drosophila has identified early active regionalizing leg genes (e.g. dac and Dll, upper image), as well as late acting genes specifying leg joints (lower image), but the regulatory steps in-between are not understood (for images see a PDF of this advertisement: https://faubox.rrze.uni-erlangen.de/dl/fiHVCsGFL63w1Bsa9VCdh9nU/?inline.)

While appendages in Drosophila develop from imaginal discs deep within the larval body, in our model system Tribolium castaneum the legs develop during embryogenesis and can easily be monitored by live imaging. A multitude of genetic and molecular techniques are available in this beetle, including CRISPR, RNAi and transgenics, as well as genomic and imaging methods.