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Archiv-Übersicht     Angebot Nr. 13585

Angebotsdatum: 2. September 2019
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Physik > Kristallographie
Titel des Themas: New models for macromolecular crystal structures

Institut: University of Wuerzburg
Frau Andrea Thorn
Josef-Schneider-Str. 2
97080 Würzburg
Tel.:    Fax.:
Bundesland: Bayern
Homepage: http://https://www.uni-wuerzburg.de/en/rvz/research/associated-research-groups/thorn-group/
E-Mail Kontakt: mail

Beschreibung: Macromolecular X-ray structures define molecular biology. However, the large discrepancy between the measured X-ray data and the structural models we use to interpret these data (as evidenced by residual values of 15-25%) clearly shows that something is amiss. The Thorn lab aims to discover what is missing, using both practical experiments and ‘big data’ analyses (including machine learning). Subsequently, this knowledge will be implemented to fundamentally improve X-ray data quality and structural models. In this exciting research project you will improve how well we understand, measure and model macromolecular crystal structures to enable structural biologists to extract more information from the over 100,000 already known biological structures, solve more borderline cases and ultimately, to answer more challenging biological questions.

The Thorn lab is working in close collaboration with other well-known institutions in Germany, France, Sweden and the UK. You will have the opportunity to visit collaborators and to present your work at international workshops and conferences. Furthermore, you will be expected to contribute on occasion to teaching and public outreach.
Methoden: Crystallography
Data analysis
Software Development (C++ and/or python)
Molecular Biology
Machine Learning
Anfangsdatum: 2. September 2019
Geschätzte Dauer: 3 years
Bezahlung: TVL-E 13
Sonstiges: We offer a 36-month full- or part-time position at the Rudolf-Virchow Center (RVZ) of the University Würzburg, the birthplace of X-rays, with a competitive salary commensurate with your training and experience according to salary agreement TV-L. Your position is funded by the Deutsche Forschungsgemeinschaft (DFG) as part of the project “Towards a better understanding of macromolecular X-ray structures”.

This rewarding and challenging research project will allow you to acquire skills in applied structural biology, its theoretical foundations and in software development. While often theoretical in nature, our work is deeply rooted in experiments: you will have access to state-of-the-art lab equipment and receive training in advanced macromolecular structure solution.

Our group is well-connected and we maintain close ties with other method developers worldwide, giving us access to a wide range of skills and training opportunities. Through the Würzburg Graduate School for Life Sciences (GSLS) you will have a personal thesis committee to guide you and will benefit from an extensive transferable skill program, travel funding and administrative support.

You will have access to both national and the public-service pension schemes (VBL), health care, and 30 days of holiday entitlement (if working full-time) in addition to 13 annual public holidays in Bavaria. The JMU Welcome Center supports international candidates with finding accommodation, general information regarding taxes, insurance, healthcare and other administrative matters. The University also offers support for candidates with children, including the University kindergarten, advice regarding school placement, holiday programs and flexible work hours.