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Archiv-Übersicht     Angebot Nr. 13611

Angebotsdatum: 16. September 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: PhD in Molecular Obesity Research

Institut: Helmholtz-Institut für Metabolismus-, Adipositas- und Gefäßforschung, HI-MAG, Leipzig
Dr. rer. nat. John Heiker
Philipp-Rosenthal-Str. 27
04103 Leipzig
Tel.:    Fax.:
Bundesland: Sachsen
Homepage: http:// http://https://www.helmholtz-muenchen.de/hi-mag/research/obesity-research/junior-research-group-molecular-obesity-research/main-projects/index.html
E-Mail Kontakt: mail

Beschreibung: Key topics of the new Helmholtz Institute in Leipzig include regulation of appetite and satiety, molecular mechanisms of adipose tissue dysfunction in obesity, target identification and validation for obesity pharmacotherapy, and develop novel vascular drug delivery systems and targets, novel biomarkers for personalized peripheral arterial restenosis prevention. Deeply integrated in the Leipzig University Medicine campus with its highly active inpatient, outpatient and clinical trials activities it is perfectly set up to accomplish true bed-to-bedside-to-bed scientific progress.

Obesity is a multifactorial disorder influenced by a combination of genetic, behavioural, life style and environmental factors. These factors and their interaction cause expanding fat mass, adverse fat distribution and adipose tissue dysfunction, which promote a pro-inflammatory, diabetogenic and atherogenic adipokine pattern that contributes to endorgan damage and comorbid diseases.

This Project is working on the question, which fat derived “signals” (adipokines) contribute to obesity related diseases and how do they function on the molecular level?

We seek a motivated and open-minded PhD student holding a recent M.Sc. degree in Biochemistry or Biology (or equivalent) with strong interest in protein biochemistry. A solid background and practical experience in recombinant protein expression and purification is beneficial. Experience in methods listed below are a plus.

The successful candidate should be able to work independently as well as in a team, have good communication skills, and an excellent level of written and spoken English. Professional self-organization and data-handling are mandatory.
We offer modern equipment, a multi-disciplinary approach with state-of-the-art techniques, and a good working atmosphere in a young team.

Funding of the position is for 4 years with a salary according to TVL13-65%.
Please send your application including motivation letter, CV, copies of certificates, abstract of Master's thesis and contact information of references (in a single pdf file) using the email link above.

Review of applications will begin immediately and applications will be accepted until the position is filled.
Methoden: Our group ‘Molecular Obesity Research’ pursues several approaches to investigate adipokine functions in adipose tissue and obesity. We use our expertise in protein expression and purification to generate substantial amounts of these proteins and elucidate the structural characteristics and molecular mechanisms underlying their biologic activity. In parallel, we are dedicated to unravel their physiological function in health and disease using isolated cells, tissues and animal models.

Biochemical / molecular biology methods include:

recombinant protein expression and purification (e.g. Aekta FPLC), micro scale thermophoresis, MALDI-ToF-MS, CD-spectroscopy, real time-PCR, ELISA, immuno-precipitation, enzyme assays, identication of protein-protein and protein-ligand/cofactor interactions
cloning, site-directed mutagenesis, cell culture, stably transfected cell lines, adipocyte differentiation, study of lipid accumulation, glucose uptake, lipolysis, intracellular signalling cascades
Anfangsdatum: 16. September 2019
Geschätzte Dauer: 4 years