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Archiv-Übersicht     Angebot Nr. 13614

Angebotsdatum: 23. September 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: The molecular function of cell adhesion molecule JAM-M

Institut: Inst. für Medizinische Biochemie, ZMBE
Adresse:
Prof. Klaus Ebnet
Von-Esmarch-Str. 56
48149 Münster
Tel.: 0251 8352127   Fax.: 0251 8356748
Bundesland: Nordrhein-Westfalen
Homepage: http://https://www.medizin.uni-muenster.de/zmbe/die-institute-des-zmbe/inst-fuer-medizinische-biochemie/institutassoziierte-forschergruppe-prof-ebnet/
E-Mail Kontakt: mail

Beschreibung: We study the role of cell adhesion molecules of the JAM family in epithelial cells, endothelial cells and tumor cells. We have recently identified a novel JAM family member called JAM-M. JAM-M is localized at the brush border of cultured epithelial cells and is expressed by a specific subset of intestinal epithelial cells, in which it might play a role in brush border dynamics after helminth infection. In this project, we will study the role of JAM-M in the small intestine and in small intestine-derived organoids derived from mice. In our projects, we apply primarily methods of molecular biology, protein biochemistry and fluorescence microscopy. This project will largely make use of immunohistochemistry and high resolution microscopy. You should be interested in molecular cell biology, open to new technologies, and highly motivated. A willingness to work with laboratory animals will be essential. We offer an exciting new project, intensive supervision, and a strong scientific environment. For additional information, feel free to contact us by telephone or e-mail, or visit our web site ("zmbe münster"). If you are interested, please send your application as a pdf document to the indicated address.
Methoden: molecular biology, protein biochemistry, microscopy, cell and tissue culture, intestinal organoids, immunohistochemistry
Anfangsdatum: 23. September 2019
Geschätzte Dauer: 3 Jahre
Bezahlung: TV-L E13/65%
Papers: REVIEWS:

1. Steinbacher T, Kummer D and Ebnet K (2018). Junctional Adhesion Molecule-A: Functional diversity through molecular promiscuity. Cell. Mol. Life Sci.75:1393–1409.

2. Kummer D and Ebnet K (2018). Junctional Adhesion Molecules (JAMs): The JAM - Integrin connection. Cells. Mar 26;7(4). pii: E25. doi: 10.3390/cells7040025.

3. Ebnet K (2017). Junctional adhesion molecules (JAMs): Cell adhesion receptors with pleiotropic functions in cell physiology and development. Physiol. Rev. 97: 1529-1554


ORIGINAL ARTICLES

1. Otani T, Nguyen TP, Tokuda S, Sugihara K, Sugawara T, Furuse K, Miura T, Ebnet K, Furuse M (2019). Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity. J. Cell Biol. Aug 29. pii: jcb.201812157. doi: 10.1083/jcb.201812157. [Epub ahead of print].

2. Riddell M, Nakayama A, Hikita T, Mirzapourshafiyi F, Kawamura T, Pasha A, Li M, Masuzawa M, Looso M, Steinbacher T, Ebnet K, Potente M, Hirose T, Ohno S, Fleming I, Gattenlöhner S, Aung PP, Phung T, Yamasaki O, Yanagi T, Umemura H, Nakayama M.(2018). aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA binding ability. Nat Commun. 2018 Dec 17;9(1):5357. doi: 10.1038/s41467-018-07739-0.

3. Fededa JP, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich JA and Gerlich DW (2016). MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J. 35: 2386–2398.

4. Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V and *Ebnet K (2016). VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation. Mol.Biol.Cell 27: 2811-2821.

5. Fededa JP, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich JA and Gerlich DW (2016). MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J. 35: 2386–2398.

6. Squarr AJ, Brinkmann K, Chen B, Steinbacher T, Ebnet K, Rosen MK and Bogdan S (2016). Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation. J. Cell Biol. 212: 591-603.

7. Tuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S and *Ebnet K (2015). JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128.
Sonstiges: The position is immediately open.

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