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Archiv-Übersicht     Angebot Nr. 13658

Angebotsdatum: 18. Oktober 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Chemie > Biochemie
Titel des Themas: Light-Oxygen-Voltage Photoreceptors, Signal Transduction & Optogenetics

Institut: Biochemie
Adresse:
Prof. Andreas Möglich
Universitätsstr. 30
95447 Bayreuth
Tel.:    Fax.:
Bundesland: Bayern
Homepage: http://www.moeglich.uni-bayreuth.de
E-Mail Kontakt: mail

Beschreibung: We are currently seeking a talented PhD student to join our team at the Department of Biochemistry of the University of Bayreuth. We investigate sensory photoreceptors which enable the control by light of behaviour and physiology in Nature and optogenetics.
The present project, funded by the Deutsche Forschungsgemeinschaft, focuses on the newly discovered light-oxygen-voltage (LOV) receptor PAL that binds short RNAs under blue light. We seek a molecular understanding of signal transduction in this and related LOV receptors. Empowered by such knowledge, we engineer photoreceptors and develop novel applications in optoribogenetics, a hitherto inaccessible branch of optogenetics.

Methoden: We use an assortment of biochemical/biophysical techniques spanning molecular biology, protein biochemistry, optical spectroscopy, electrochemistry, protein engineering, high-throughput screening, synthetic biology and X-ray crystallography.
Anfangsdatum: 18. Oktober 2019
Geschätzte Dauer: 3 years
Bezahlung:
Papers: More information is available on request or can be found in our recent publications, cf. e.g., Nat Commun 2015 (26648256), ACS Synth Biol 2016 (27002379), Nucleic Acid Res 2016 (27744350), Structure 2017 (28502782), Nat Commun 2017 (28819239), Chem Rev 2018 (29984995), Nat Chem Biol 2019 (31451761).
Sonstiges: The Department of Biochemistry at the University of Bayreuth provides top-notch instrumentation for biochemistry, electrochemistry, protein crystallography, optical spectroscopy, mass spectrometry and flow cytometry. By offering excellent training and research infrastructure, the institute and the university create a highly interdisciplinary and stimulating environment for biochemical projects. The PhD student can enroll in the University of Bayreuth graduate school BayNAT.

Applications should be sent as a single PDF to the below email address and comprise CV, motivation letter and contact information for two referees willing to provide reference letters.
(andreas.moeglich@uni-bayreuth.de)

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