Zur Startseite von DrArbeit.de,
der deutschlandweiten Stellenbörse für Diplomarbeiten und Doktorarbeiten


Lupe2

Archiv - Stellenangebot

 

Dies ist ein Angebot aus der Datenbank von DrArbeit.de

Um die Datenbank komfortabel nach weiteren Angeboten durchsuchen zu können, klicken Sie einfach oben oder hier.

 
Archiv-Übersicht     Angebot Nr. 13660

Angebotsdatum: 20. Oktober 2019
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Entwicklungsbiologie
Titel des Themas: Cellular and genetic basis underlying heterochronic brain development

Institut: Abt. für Evolutionäre Entwicklungsgenetik
Adresse:
Prof. Gregor Bucher
Justus-von-Liebig-Weg 11
37077 Göttingen
Tel.:    Fax.:
Bundesland: Niedersachsen
Homepage: http://https://www.uni-goettingen.de/de/2794.html?cid=14631
E-Mail Kontakt: mail

Beschreibung: The cellular and genetic mechanisms of brain evolution remain enigmatic. We have been comparing the development of the vinegar fly Drosophila and the red flour beetle Tribolium to understand the diversification of brains and have established genetic neural lineages as novel tool. In this DFG funded project you will follow three questions: To what degree are neurons expressing an orthologous transcription factor conserved between insects? In what respects does the development of homologous cells deviate? What is the genetic control of these differences? You will use genome editing to generate imaging lines and adopt the brainbow system to Tribolium. Using RNAi you will identify the genetic bases of differences of brain development.
Methoden: CRISPR/Cas9n genome editing
generation of transgenic lines
RNAi
confocal imaging of brains

Interface between developmental biology and evolution.
Anfangsdatum: 1. Februar 2020
Geschätzte Dauer: 3-4
Bezahlung: TVL-E13 (50%, then 65%)
Papers: He B, Büscher M, Farnworth M.S, Strobl F, Stelzer E, Koniszewski NDB, Mühlen D, Bucher G (2019) An ancestral apical brain region contributes to the central complex under the control of foxQ2 in the beetle Tribolium eLife 2019;8:e49065

Koniszewski*, NDB, Kollmann* M, Bigham M, Farnworth M, He B, Büscher M, Hütteroth W, Binzer M, Schachtner J, Bucher, G. The insect central complex as model for heterochronic brain development-background, concepts, and tools. Dev. Genes Evol. 2016;226:209-19.
Sonstiges: You should hold a Master degree (or equivalent) in Biology or related fields and have a strong interest in developmental genetics of the brain and its evolution. A solid technical background in molecular genetic work (e.g. DNA, RNA, RNAi, genome editing etc.) and/or confocal brain imaging would be welcome. You should like to work in a closely collaborating and interactive team and you should show a high degree of independence in experimental planning and interpretation. Your work will be embedded in the emerging focus on molecular genetics in zoological and evolutionary questions at the University of Göttingen, which is one of the top German universities. Your will join one of our structured PhD programs.
The University of Göttingen belongs to the top group of research universities in Germany.

Archiv-Übersicht