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Archiv-Übersicht     Angebot Nr. 13677

Angebotsdatum: 30. Oktober 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: PhD Postion in Epigenetics

Institut: Institute of Molecular Biology and Tumorbiology (IMT) Philipps University Marburg
Dr. rer. nat. Jacqueline Mermoud
Hans-Meerwein-Str. 2
35043 Marburg
Tel.:    Fax.:
Bundesland: Hessen
Homepage: http://www.imt.uni-marburg.de/mermoud/index.php
E-Mail Kontakt: mail

Beschreibung: PhD position (biologischer Doktorand) on epigenetic control of mammalian genome function in the research group of Dr J. Mermoud.

Our group at the Institute of Molecular Biology and Tumorbiology (IMT) of the Philipps-University in Marburg dissects the epigenetic basis of cell identity to understand its mis-regulation in diseases.

THE PROJECT involves fundamental research on chromatin-based mechanisms of gene regulation and transposon silencing. The main focus of the lab is to understand the principles that underpin transcriptional repression and heterochromatin formation as these processes are critical for cell function and genome stability. We recently discovered that an ATP dependent chromatin remodeling enzyme called SMARCAD1 restrains the activity of mobile elements in pluripotent cells. Loss of SMARCAD1 function leads to transcriptional up regulation of endogenous retroviruses and nearby host genes. The successful candidate will determine the molecular mechanisms of how SMARCAD1 establishes heterochromatin organisation and transcriptional repression of repetitive elements and genes and the role of this remodelling enzyme in maintaining transcriptional repression through the cell cycle. In a complementary project, the human skin specific isoform of SMARCAD1 will be investigated which, when mutated, causes lack of fingerprints, referred to as immigration delay disease. For details refer to our recent publication (Sachs at al., Nature communications 2019) and http://www.imt.uni-marburg.de/mermoud/index.php

+ The IMT pursues an excellent research program and has a top-notch infrastructure with access to state of the art core facilities.
+ We are associated with a transregional, collaborative chromatin research network (DFG TRR81; Bad Nauheim, Giessen, Marburg, Rotterdam) aimed at obtaining a profound molecular understanding of chromatin changes in Differentiation and Malignancies.
+ The successful candidate will take part in a Training Program and obtain optimal support to develop strong research and soft skills which will help to achieve their scientific and career goals.
+ The Mermoud lab has an excellent track record of past students who have published well, allowing them to move on to internationally renown labs.
+ Being part of a thriving academic and social community in Marburg, an attractive student town in the heart of Germany.
+ The Philipps-University promotes equal opportunity and provides a friendly, dynamic working environment.
+ The position is paid in accordance to DFG rates and is available immediately.

Methoden: The project combines biochemistry, molecular and cell biology, including epigenome technology. Methods used in the lab include whole transcriptome profiling and genome wide chromatin immunoprecipitation coupled to Next Generation Sequencing (NGS) with subsequent bioinformatics, mechanistic and functional analysis of chromatin associated proteins, e.g. with CRISPR/Cas9 technology and in vivo mouse embryonic stem cells and their differentiated derivatives.
Anfangsdatum: 20. Januar 2020
Geschätzte Dauer: 3 Jahre
Bezahlung: E13 50%
Papers: Sachs at al., Nature communications 2019
Sonstiges: PhD student candidates must have a master degree in Molecular Biology (or similar subject) and a proven track record in research and laboratory work. Ability to communicate in written and spoken English is required. Proficiency in bioinformatics or chromatin biology is an advantage.

E mail a single PDF, including cover letter, CV, information on years of experience in research and laboratory work including the methods applied, academic transcripts, and contact details of referees to mermoud@imt.uni-marburg.de. Deadline 29th of November 2019. Only shortlisted applicants will be notified.