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Archiv-Übersicht     Angebot Nr. 13680

Angebotsdatum: 3. November 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Neurobiologie
Titel des Themas: Elucidating platelet-immune cell interactions in ischemic stroke

Institut: Institut für Experimentelle Biomedizin - Universitätsklinikum Würzburg
Adresse:
Dr. rer. nat. David Stegner
Josef-Schneider-Str. 2, D15
97080 Würzburg
Tel.:    Fax.:
Bundesland: Bayern
Homepage: http://www.platelets.eu/career/
E-Mail Kontakt: mail

Beschreibung: Platelet activation at sites of vascular injury is essential for hemostasis, but in diseased vessels it can also lead to ischemic events, such as heart attack and stroke. Moreover, the interaction of platelets with cells of the immune system (“thrombo-inflammation”) is critically involved in the pathogenesis of inflammatory disease states.
Our interdisciplinary research team investigates the cellular and molecular mechanisms of thrombo-inflammatory diseases, such as ischemic stroke or liver inflammation. Our long-term goal is to identify novel targets for the development of improved therapies against vascular diseases.
The PhD project will include the use of cutting edge imaging techniques, cell biology, molecular biology, biochemistry and mouse genetics, and will have a strong biomedical/translational context. We offer the opportunity to work in an excellent scientific environment and to collaborate with international research groups, as well as a pleasant working atmosphere.
Methoden: Elucidating platelet-immune cell interactions in ischemic stroke
Our interdisciplinary research team investigates the cellular and molecular mechanisms of ischemic stroke, one of the most common causes of physical disability worldwide. Apart from the contribution of platelets to the primary vascular occlusion, they are also significantly involved in the regulation of "thrombo-inflammatory" processes and the resulting brain damage after ischemic stroke. Besides platelets also immune cells contribute to infarct progression. The underlying mechanisms are, however, largely unknown.
This PhD project will study the role of platelet receptors on infarct progression in ischemic stroke. In vitro and in vivo models of ischemic stroke will be combined with advanced imaging techniques to decipher the molecular interplay of platelets and immune cells in the context of ischemic stroke. Moreover, in a translational approach, antibodies against newly identified targets will be generated and characterized.
Anfangsdatum: 3. November 2019
Geschätzte Dauer: 3 Jahre
Bezahlung: TV-L 13, 65%
Papers: van Eeuwijk JM, Stegner D, Lamb DJ, Kraft P, Beck S, Thielmann I, Kiefer F, Walzog B, Stoll G, Nieswandt B. The Novel Oral Syk Inhibitor, Bl1002494, Protects Mice From Arterial Thrombosis and Thromboinflammatory Brain Infarction. Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1247-53.

Stegner D, Thielmann I, Kraft P, Frohman MA, Stoll G, Nieswandt B. Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2212-7.

Stegner D, Hofmann S, Schuhmann MK, Kraft P, Herrmann AM, Popp S, Höhn M, Popp M, Klaus V, Post A, Kleinschnitz C, Braun A, Meuth SG, Lesch KP, Stoll G, Kraft R, Nieswandt B. Loss of Orai2-Mediated Capacitative Ca(2+) Entry Is Neuroprotective in Acute Ischemic Stroke. Stroke. 2019 Nov;50(11):3238-3245.

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle
T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G,
Stegner D, Nieswandt B. Gray platelet syndrome and defective thrombo-inflammation
in Nbeal2-deficient mice. J Clin Invest. 2013 Jul 1. pii: 69210.
Sonstiges: Qualification profile
Suitable candidates should hold a Master’s degree or equivalent in a life sciences subject with a strong interest in molecular and (vascular) cell biology/immunology, mouse models and different imaging techniques. Excellent lab skills and good knowledge of the English language are a prerequisite. Previous experience with in vivo work and/or advanced imaging techniques is highly advantageous.

Benefits
We offer an international and excellent scientific environment that is embedded in the framework of a new German wide research consortium on platelets (http://www.tr240.de). Its infrastructure is unique in the platelet research field and offers the opportunity to collaborate with national and international basic and translational research groups. The research lab consists of several post-doctoral scientists, PhD students, master students and research assistants.
As a PhD student you will have the opportunity to become part of the international ‘Graduate School of Life Sciences’ (GSLS) (http://www.graduateschools.uni-wuerzburg.de/life_sciences). The university furthermore offers comprehensive services concerning administrative and practical matters, e.g. the Welcome Centre (moving to Würzburg) and the International Office.
The salary for this temporary position is commensurate with training and experience according to Collective Agreement for the Public Service of German Federal States TV-L (E13 (65%)). We particularly encourage female scientists to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.

Send applications to
The position will start on January 15th, 2020 or later. Applications should be sent as a single pdf-document including application letter, curriculum vitae, certificates including contact details of two references by e-mail until November 30, 2019 to Dr. David Stegner (career@platelets.eu)
For further questions, please do not hesitate to contact Dr. David Stegner (stegner@virchow.uni-wuerzburg.de)

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