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Archiv-Übersicht     Angebot Nr. 13681

Angebotsdatum: 3. November 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Platelets as modulators of liver inflammation and resolution

Institut: Institut für Experimentelle Biomedizin - Universitätsklinikum Würzburg
Adresse:
Dr. rer. nat. David Stegner
Josef-Schneider-Str. 2, D15
97080 Würzburg
Tel.:    Fax.:
Bundesland: Bayern
Homepage: http://www.platelets.eu/career/
E-Mail Kontakt: mail

Beschreibung: Platelet activation at sites of vascular injury is essential for hemostasis, but in diseased vessels it can also lead to ischemic events, such as heart attack and stroke. Moreover, the interaction of platelets with cells of the immune system (“thrombo-inflammation”) is critically involved in the pathogenesis of inflammatory disease states.
Our interdisciplinary research team investigates the cellular and molecular mechanisms of thrombo-inflammatory diseases, such as ischemic stroke or liver inflammation. Our long-term goal is to identify novel targets for the development of improved therapies against vascular diseases.
The PhD project will include the use of cutting edge imaging techniques, cell biology, molecular biology, biochemistry and mouse genetics, and will have a strong biomedical/translational context. We offer the opportunity to work in an excellent scientific environment and to collaborate with international research groups, as well as a pleasant working atmosphere.
Methoden: Platelets as modulators of liver inflammation and resolution
Ischemic stroke or liver transplantation result in a lack of oxygen supply, that is detrimental to the affected tissue. However, the return of blood supply is accompanied by an aggravating damage due to the so-called reperfusion injury. This tissue damage is caused by over-shooting thrombotic and inflammatory processes and insufficient resolution of inflammation. However, the precise cellular interplay underlying reperfusion injury is only partially understood.
This PhD project will combine murine models of hepatic injury with advanced ima-ging techniques to dissect the thrombo-inflammatory pathomechanisms underlying reperfusion injury and the subsequent resolution of inflammation. Confocal intravital fluorescence microscopy will be applied in order to visualize complex cellular interactions between platelets, leukocytes and endothelial cells in the ischemic liver. Besides imaging, functional cellular assays as well as biochemical and molecular biology approaches will be part of the PhD project.
Anfangsdatum: 3. November 2019
Geschätzte Dauer: 3 Jahre
Bezahlung: TV-L 13, 65%
Papers: Stegner D, vanEeuwijk JMM, Angay O, Gorelashvili MG, Semeniak D, Pinnecker J, Schmithausen P, Meyer I, Friedrich M, Dütting S, Brede C, Beilhack A, Schulze H, Nieswandt B, Heinze KG. Thrombopoiesis is spatially regulated by the bone marrow vasculature. Nat Commun. 2017 Jul 25;8(1):127.

Stegner D, Popp M, Lorenz V, Wax JK, Gessner JE, Nieswandt B. FcgRIIB on liver sinusoidal endothelial cells is essential for antibody-induced GPVI ectodomain shedding in mice. Blood. 2016 Aug 11;128(6):862-5.

Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B. Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice. J Clin Invest. 2013 Jul 1. pii: 69210.
Sonstiges: Qualification profile
Suitable candidates should hold a Master’s degree or equivalent in a life sciences subject with a strong interest in molecular and (vascular) cell biology/immunology, mouse models and different imaging techniques. Excellent lab skills and good knowledge of the English language are a prerequisite. Previous experience with in vivo work and/or advanced imaging techniques is highly advantageous.

Benefits
We offer an international and excellent scientific environment that is embedded in the framework of a new German wide research consortium on platelets (http://www.tr240.de). Its infrastructure is unique in the platelet research field and offers the opportunity to collaborate with national and international basic and translational research groups. The research lab consists of several post-doctoral scientists, PhD students, master students and research assistants. As a PhD student you will have the opportunity to become part of the international ‘Graduate School of Life Sciences’ (GSLS) (http://www.graduateschools.uni-wuerzburg.de/life_sciences). The university furthermore offers comprehensive services concerning administrative and practical matters, e.g. the Welcome Centre (moving to Würzburg) and the International Office.
The salary for this temporary position is commensurate with training and experience according to Collective Agreement for the Public Service of German Federal States TV-L (E13 (65%)). We particularly encourage female scientists to apply. Disabled applicants will be preferentially considered in case of equivalent qualification.

Send applications to
The position will start on January 15th, 2020 or later. Applications should be sent as a single pdf-document including application letter, curriculum vitae, certificates including contact details of two references by e-mail until November 30, 2019 to Dr. David Stegner (career@platelets.eu)
For further questions, please do not hesitate to contact Dr. David Stegner (stegner@virchow.uni-wuerzburg.de)

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