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Archiv-Übersicht     Angebot Nr. 13699

Angebotsdatum: 11. Dezember 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: Functional Characterization of novel Histone Phosphorylations

Institut: Institute for Biochemistry
Adresse:
Prof. Lienhard Schmitz
Friedrichstrasse 24
35392 Giessen
Tel.:    Fax.:
Bundesland: Hessen
Homepage:
E-Mail Kontakt: mail

Beschreibung: This project is part of the TRR81 "Chromatin Changes in Differentiation and Malignancies" and the position is immediately available till June 2022.
In this project we will further investigate the role of the recently discovered histone H2B phosphorylation at serine 6 (PMID: 30765437). The regulation of this mitotic phosphorylation by phosphatases and the influence of genetic instability of tumor cells on the spatial and temporal distribution of this phosphorylation are studied. The interplay with further mitotic phosphorylations and further protein kinase networks is investigated by high resolution microscopy. The association of H2B phosphorylation with basal and inducible gene expression is studied by ChIP-seq experiments.
Methoden: This demanding project involves a large spectrum of different methods from biochemistry, molecular biology and virology.
Anfangsdatum: 11. Dezember 2019
Geschätzte Dauer: 2,5 Jahre
Bezahlung: TV-H E13 (65 %)
Papers: http://www.ncbi.nlm.nih.gov/pubmed/?term=schmitz+ml+Not+rock+Not+children+Not+aarhus+Not+Atlanta+Or+Lienhard+Schmitz
Sonstiges: The university is an equal opportunity employer, and applications from women or candidates with children are encouraged. Applications of severely disabled with same suitability are preferred.
Please send your CV, two names of reference and the further usual documents to

Prof. M.L. Schmitz
Biochemical Institute
Friedrichstrasse 24
35392 Giessen (Germany)
e-Mail: lienhard.schmitz@gmx.de

Please send your application per mail or in paper, please note that we cannot send your papers back after termination of the application procedure.

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