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Archiv-Übersicht     Angebot Nr. 13721

Angebotsdatum: 9. Dezember 2019
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Neurobiologie
Titel des Themas: Sodium Channels and Pain

Institut: Clinic for Anesthesiology and Intensive Care
Prof. Enrico Leipold
Ratzeburger Allee 160
23562 Luebeck
Tel.: +49 451 3101 8610   Fax.:
Bundesland: Schleswig-Holstein
Homepage: http://https://www.cbbm.uni-luebeck.de/forschungszentrum/arbeitsgruppen/leipold.html
E-Mail Kontakt: mail

Beschreibung: Voltage-gated sodium channels (NaV channels) of nociceptive afferents (pain receptors) trigger action potentials which transmit the pain information to the central nervous system. Recently, we demonstrated that functional alterations of sodium channel subtype NaV1.9 cause either congenital analgesia or severe episodic pain attacks in affected patients (Nat Genet 45: 1399-1404; Nat comm 6: 10049). It is still unknown how functional alterations of NaV1.9 channels can cause these two opposing phenotypes. In this project we aim to identify the molecular mechanisms underlying the NaV1.9-dependent pain phenotypes congenital analgesia and severe episodic pain attacks.
Methoden: The methods used in this project are electrophysiological assays (patch-clamp technique, extracellular recordings), molecular biology techniques (e.g. PCR-based DNA mutagenesis), culturing and transfection of mammalian cells as well as the isolation of primary neurons from animal tissue. All methods are well established in the group.
Anfangsdatum: 9. Dezember 2019
Geschätzte Dauer: 36 month
Bezahlung: E13 (65%)
Papers: Nat Genet 45: 1399-1404
Nat comm 6: 10049
Sonstiges: Requirements:
We are looking for an enthusiastic and highly motivated candidate who holds a degree in biology, biochemistry, biophysics, molecular life sciences, medicine or a similar subject and who has a strong interest to work on interdisciplinary scientific questions. The ideal candidate has a profound knowledge of neuroscience and has already gained initial experience in electrophysiology. Furthermore, we expect solid hands-on laboratory experience, good communication skills and the ability to work in a team.