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Archiv-Übersicht     Angebot Nr. 13732

Angebotsdatum: 13. Dezember 2019
Art der Stelle: Doktorarbeit
Fachgebiet: Mathematik > Angewandte Mathematik
Titel des Themas: Game Theory of Cancer Dormancy and Bone Metastasis

Institut: Max Planck Institute of Colloids and Interfaces
Dr. rer. nat. Amaia Cipitria
Am Mühlenberg 1
14476 Potsdam
Tel.:    Fax.:
Bundesland: Brandenburg
Homepage: http://https://imprs.mpikg.mpg.de/research/projects-2020/prj2k20-16
E-Mail Kontakt: mail

Beschreibung: Cancer cells disseminate from the primary tumor and home to secondary
organs where they can survive dormant for years, before becoming proliferative and leading to
metastasis (1). We aim to model interactions between disseminated cancer cells and the bone
microenvironment as a spatial evolutionary game (2). The model will (i) analyze the stable
scenarios, where various bone cell populations co-exist with cancer cells, including realistic
geometric constraints, such as the bone structure, and comparisons with experimental data,
and thereby (ii) describe the path from an initial population of latent cancer cells to irreversible
overt metastasis. First, a model of physiological bone remodeling will recapitulate the stable
population balance between different kind of bone cells. Second, a model of pathological bone
metastasis will capture the loss of stability in the formation-resorption process, when cancer
cells are introduced as a new strategy, leading to bone destruction. Last, the nature of the
cancer cells could be variable, from
dormant, to slowly cycling to highly
proliferative, in order to model the
transition from cancer dormancy to bone
metastasis. A special emphasis is laid on
interdisciplinary research and close
collaboration with scientists working
with experimental cancer models
will be expected.
Methoden: theoretical and mathematical modeling, strong interest in the biology of
cancer and bone metastasis
Anfangsdatum: 1. August 2020
Geschätzte Dauer: 3 Jahre
Bezahlung: Vertrag
Papers: 1. Aguirre-Ghiso, J. A. (2007). Models, mechanisms and clinical evidence for cancer dormancy.
Nature Reviews Cancer, 7(11), 834–846.
2. Ryser, M. D., & Murgas, K. A. (2017). Bone remodeling as a spatial evolutionary game.
Journal of Theoretical Biology, 418, 16–26.
Sonstiges: Host group website http://www.mpikg.mpg.de/5860422/extracellular-matrix-in-disease-and-regeneration; starting time is flexible - autumn of 2020