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Archiv-Übersicht     Angebot Nr. 13811

Angebotsdatum: 25. Februar 2020
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Biochemie
Titel des Themas: Stress-induced ribosome heterogeneity

Institut: Institut für Biochemie und Molekularbiologie
Prof. Hans-Georg Koch
Stefan Meier Strasse 17
79104 Freiburg
Tel.: 0761/2035250   Fax.: 0761/203/5289
Homepage: http://https://www.biochemie.uni-freiburg.de/en/ag/koch
E-Mail Kontakt: mail

The ribosome is a large cellular machinery that translates the genetic information into function and thus controls gene expression. Originally the ribosome was considered to be an invariable entity of ribosomal proteins and rRNA that together with translation factors sustains protein synthesis. However, there is increasing evidence for ribosome heterogeneity in prokaryotic and eukaryotic cells that facilitates the dynamic amendment of protein synthesis and ribosome-associated processes to different metabolic and environmental conditions. Our goal is to analyse how dynamic ribosome modifications and specialized ribosomal subpopulations determine protein homeostasis in response to different cellular signals.

We are an international and highly motivated research team that follows an interdisciplinary approach with a wide range of biochemical, biophysical, microscopic and mass spectrometry-based methods. We are working in a very attractive scientific environment and in one of the most beautiful parts of Germany.

The position is funded by the German Science Foundation (DFG) via the CRC 1381 (https://www.sfb1381.uni-freiburg.de) and training within a structured program is provided.

We are looking for highly motivated PhD applicants with a Master’s degree in life sciences and a strong background in Microbiology/Cell Biology and/or Biochemistry/Biophysics. Experience in analysing ribosome-associated processes will be advantageous. Solid proficiency in English is required.

Please send your application including a motivation letter, your CV, records of your Bachelor and Master studies with the important certificates and two letters of reference via Email until March 15th 2020. Informal inquiries about the position and the requirements for obtaining a PhD in Germany are welcome.

Methoden: high resolution microscopy; in vitro transcription/translation; site directed cross-linking; cell fractionation, mass spectrometry; metabolomics
Anfangsdatum: 1. Juni 2020
Geschätzte Dauer: 3-4 years
Bezahlung: TV-L13/65%
Papers: Kuhn, P., Draycheva, A., Vogt, A., Petriman, N.A., Sturm, L., Drepper, F., Warscheid, B., Wintermeyer, W., and Koch, H.G. (2015) J. Cell Biol. 211, 91-104
Denks, K., Sliwinski, N., Erichsen, V., Borodkina, B., Origi, A. and Koch, H.G. (2017) Nature Microbiology, 2, 16265
Marckmann D, Trasnea PI, Schimpf J, Winterstein C, Andrei A, Schmollinger S, Blaby-Haas CE, Friedrich T, Daldal F, Koch HG. (2019). Proc Natl Acad Sci U S A doi:10.1128/mBio.01317-19.