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Archiv-Übersicht     Angebot Nr. 13833

Angebotsdatum: 10. März 2020
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Physiologie
Titel des Themas: Doctoral Research Fellow for a DFG-funded project regarding the impact of the mineralocorticoid receptor in liver cirrhosis

Institut: Julius Bernstein Institut für Physiologie
PD Barbara Schreier
Magdeburger Str. 6
06112 Halle/Saale
Tel.: 03455574759   Fax.:
Bundesland: Sachsen-Anhalt
Homepage: http://https://www.medizin.uni-halle.de/index.php?id=272
E-Mail Kontakt: mail

Beschreibung: At the Martin-Luther-University Halle-Wittenberg, Faculty of Medicine, Julius-Bernstein-Institute of Physiology is, from June 1st, 2020, on 36-month temporary position for a
Doctoral Research Fellow (registration number: 7-015/20-D)available in full time (65 %)
The remuneration is paid depending on the assignment of tasks and fulfillment of the personal requirements up to the fee group E 13 TV-L.
The project is DFG-funded and aims to evaluate the impact of the mineralocorticoid receptor and its endogenous ligand, aldosterone, in the development of liver cirrhosis. The PhD-student will work in cooperation between the Julius Bernstein institute of physiology and the clinics for internal medicine I, AG molecular hepatology.
Disabled candidates with equivalent qualifications will receive preferential consideration. Women are strongly encouraged to apply.

If you have any questions please contacted PD Dr. Barbara Schreier (E-Mail: barbara.schreier@medizin.uni-halle.de, Tel.: +49-345-557-4759, Fax: +49-345-557-4019). Please send your application until the 19th of March 2020 via e-mail to barbara.schreier@medizin.uni-halle.de or via mail to the Martin-Luther-University of Halle-Wittenberg, Julius-Bernstein-Institute for Physiology, Magdeburger Straße 6, D-06112 Halle, Germany.

The call for tenders is subject to possible budgetary restrictions. Applications fees are not refunded by the Martin-Luther-University. Application documents are only returned if a sufficiently stamped return envelope has been attached.

Methoden: Conditions:
• Completed studies (MSc.) in the field of life sciences, veterinary medicine or medicine
• English skills
• Ability and willingness to participate in animal experiments
Desired knowledge and skills:
• Knowledge in the physiology/pathophysiology of the liver and the mineralocorticoid receptor
• Knowledge in the area of signal transduction and control of gene expression
• Experiences with molecular biology and protein biochemistry methods (quantitative PCR, Western Blot, ELI-SA,RNA and DNA extraction methods, reportergene assays, siRNA interference)
• Experience with cell culture techniques (including cultivation of cell lines and production of primary cultures, transmitted light and fluorescence microscopy) and the phenotyping of cell types
• Experiences with animal-experimental studies of the liver in vivo (measurement of portal, sinusoidal and arterial pressure) or ex vivo (Mulvany myography, pressure myography, histomorphometry, etc.) are desirable but not required.
Work Tasks:
• Participation in a DFG funded project on the importance of the mineralocorticoid receptor for the development and progression of liver cirrhosis.
• Implementation of experiments with rodents
• Collection of functional vascular parameters in vivo and ex vivo
• Histological and molecular biology studies on tissues
• Studies on signal transduction and gene expression on primary cell cultures and cell lines
• Data analysis, literature research and preparation of manuscripts
Anfangsdatum: 1. Juni 2020
Geschätzte Dauer: 36 months
Bezahlung: TVL-13 (65%)
Papers: Schreier B, Wolf A, Hammer S, Pohl S, Mildenberger S, Rabe S, Gekle M,
Zipprich A. The selective mineralocorticoid receptor antagonist eplerenone
prevents decompensation of the liver in cirrhosis. Br J Pharmacol. 2018
Jul;175(14):2956-2967. doi: 10.1111/bph.14341.