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Archiv-Übersicht     Angebot Nr. 13859

Angebotsdatum: 16. April 2020
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: The role of mitotic spindle misorientation in cancer formation

Institut: German Cancer Research Center, DKFZ
Prof. Ingrid Hoffmann
Im Neuenheimer Feld 242, F045
6920 Heidelberg
Tel.:    Fax.:
Bundesland: Baden-Württemberg
Homepage: http://www.dkfz.de/en/f045/index.php
E-Mail Kontakt: mail

Beschreibung: The PhD project is focused on the interplay between the formation of focal adhesions (FA) and the organization of the mitotic spindle apparatus in metastatic breast cancer.
Breast cancer is the most frequently diagnosed form of cancer and the second leading cause of cancer-related deaths among women worldwide. Correct spindle orientation is achieved through signaling pathways that provide a molecular link between the cell cortex and spindle microtubules in an F-actin-dependent manner. Mitotic spindle orientation abnormalities and loss of cell adhesion, have been proposed to facilitate cancer invasion and metastasis, yet the molecular mechanisms underlying these processes are largely unknown. To study the interplay between the two processes we will use ex vivo breast cancer models that show different characteristics in response to their invasion and metastatic properties.
Methoden: The PhD student will be using a broad range of techniques such as invasion assays, CRISPR/Cas9 technology for genomic knockins and knockouts and live cell imaging.

Anfangsdatum: 1. Juni 2020
Geschätzte Dauer: 3 years
Bezahlung: TVL-E13 (65%)
Papers: (Zhu et al., JCB 2013, 2000:773-87; Kschonsak and Hoffmann, JCS, 131(10), doi: 10.1242/jcs.214544)
Sonstiges: Applicants should hold a masters’ degree in biology /life sciences with excellent grades, background in cellular and molecular biology and have strong laboratory and analytical skills. Please send your CV, research interests, copies of certificates, transcript of records from both bachelors and masters studies, your research interests and contact addresses of two referees
Preferred starting date is june 1, 2020 but later starting times are possible.