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Archiv-Übersicht     Angebot Nr. 13868

Angebotsdatum: 25. April 2020
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: Spreading of inflammation in autoimmune diseases

Institut: Department of Rheumatology/Immunology and the German Center of Immunotherapy (DZI)
PD Andreas Ramming
Ulmenweg 18
91054 Erlangen
Tel.:    Fax.:
Bundesland: Bayern
Homepage: http://https://www.medizin3.uk-erlangen.de/en/research/research-main-focus/matrix-biology-inflammatory-pathways-in-arthritis-and-fibrosis/
E-Mail Kontakt: mail

Beschreibung: Physical barriers of the body and their immunological dysregulation are connected to a variety of inflammatory diseases and therefore an emerging area of interest in medicine. The gut and its microbiome gained center stage, whereas the skin as large primary immunological barrier to the environment is still less appreciated. Psoriatic arthritis (PsA) is a prototypic inflammatory disease which usually starts with skin lesions, before spreading to the musculoskeletal regions. To date, it is still obscure why the inflammatory process in some patients with psoriasis is restrained to the skin, whereas in other patients it extends to tendons and joints. Moreover, disease spreading to the joints associates with local tissue remodelling as evidence by new bone formation at the insertion site of tendons into the bones. This molecular and cellular regulation this “skin-joint axis” leading to development of PsA is still unclear but essential to understand organ communication in inflammatory diseases, the identification of potential biomarkers for early recognition of the disease and the development of preventive treatments.
Methoden: • Murine models of acute/chronic inflammation, tissue regeneration, fibrosis (arthritis, wound healing, psoriasis, fibrosis)

• Next generation sequencing techniques: bulk RNAseq, scRNAseq, ChIPseq, CITEseq, FISHseq, ATACseq (including supervision by experienced bioinformaticians)

• CyTOF/Hyperion (cell suspensions and tissue sections), flow cytometry, cell sorting

• Microscopy (Confocal, STED, Spinning Disc, Light Sheet, Intravital, iSCAT; including supervision by experts of Optical Imaging Center Erlangen)

• Tissue Engineering (access to 3D bioprinters, own biofabrication, 3D skin models, 3D joint models)
Anfangsdatum: 1. Juli 2020
Geschätzte Dauer: 36 months
Bezahlung: E13 65%
Papers: Wohlfahrt, T., Rauber, S., et al. (2019) PU.1 controls fibroblast polarization and tissue fibrosis. Nature 566, 344-349.

Rauber, S., Luber, M., et al. (2017) Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. Nature Medicine 23, 938-944.
Sonstiges: PhD and Postdoctoral research positions are available in the immunology laboratory of Andreas Ramming at the University of Erlangen within the Department of Rheumatology/Immunology and the German Center of Immunotherapy (DZI). Successful candidates will become part of a highly productive and collaborative team of researchers in a modern, interconnected laboratory space. Within the group, there is a strong commitment to mentorship and an excellent track record of success for both academic and industrial career tracks. Biologists, physicians, bioinformaticians and tissue engineers work together for an innovative research atmosphere.

• Candidates must possess a master and/or Ph.D. in life science areas

• High productivity demonstrated in publication record (quality and quantity)

• Strong commitment to Immunology research

• Proficiency in English and strong communication skills are necessary.

Desired Qualifications

• Preference will be given to individuals with expertise in immunology and/or molecular biology

• In vivo research experience with rodents and human tissues

• Experience with next generation sequencing techniques is preferred.

Interested individuals should send a cover letter, CV, and the names and contact information for 2-3 references to: Dr. Andreas Ramming (andreas.ramming@uk-erlangen.de). Applications will be considered on an on-going basis until the position is filled.