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Archiv-Übersicht     Angebot Nr. 13916

Angebotsdatum: 16. Juni 2020
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: Mitochondrial Development and Cristae Biogenesis

Institut: Max-Planck-Institut für Biophysikalische Chemie
Adresse:
Prof. Stefan Jakobs
Am Fassberg 11
37077 Göttingen
Tel.: 0551 201 2531   Fax.:
Bundesland: Niedersachsen
Homepage: http://www.mitoweb.de
E-Mail Kontakt: mail

Beschreibung: A PhD-student position is available through our ERC project ‘Mitochondrial Cristae Biogenesis’ (MitoCRISTAE) for a period of 3 years.

We are looking for a highly motivated and curiosity driven biologist/biochemist/biophysicist who is eager to work in a multidisciplinary team of biologists, physicists and chemists on the cell biology of mitochondria. You will help us in deciphering the mechanisms and interactions of inner-mitochondrial membrane shaping proteins that maintain the intricate mitochondrial architecture.

About the project:
The inner-mitochondrial architecture is dominated by large invaginations of the inner mitochondrial membrane: The so called “cristae”. This ultrastructure is crucial for the proper function of the mitochondria as it is the home of the oxidative phosphorylation machinery (OXPHOS) that provides our cells with the vast majority of ATP. Alterations in this structure can contribute to severe diseases like Alzheimer’s, Parkinson’s or a number of myopathies. Although the cristae are important for mitochondrial function, we are only now beginning to understand how these membrane invaginations are formed and maintained.
The goal of this project is the characterization of mitochondrial membrane shaping proteins and how their interplay contributes to the intricate mitochondrial architecture. We will use a combination of molecular and biochemical tools like CRISPR/Cas9 to create knockout cell lines of key proteins as well as super-resolution microscopy techniques (STED/MINFLUX) and 3D (cryo) electron microscopy to establish a deep, comprehensive and quantitative understanding of cristae biogenesis in human cells.

The successful candidate should have:
- Excellent degree in biology, biochemistry, biophysics or a related discipline
- Profound experience in the laboratory with a wide spectrum of methods like cell biology, biochemistry and molecular biology
- Knowledge and hands-on experience of super-resolution microscopy techniques is of advantage
- Independent thinking, structured work organization and a good team spirit are expected.
The experience gained on this project is expected to lead to independent careers in this emerging field.
The salary is in accordance with the German Public Service salary scale (TV-L E13) with 65% of the regular working hours.

Additional Information:
The research at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen/Germany encompasses a wide spectrum of scientific topics and techniques. Ultra-high-resolution microscopy, nanotechnology, nuclear magnetic resonance spectroscopy, mass spectrometry and computer simulation are employed to delve ever-further into the nanocosmos of living cells.
The research group Mitochondrial Structure and Dynamics is investigating the mechanisms by which the inner-mitochondrial architecture is determined and maintained. We are using a wide variety of experimental approaches that include molecular and biochemical tools, in particular electron and advanced super-resolution light microscopy, as well as live-cell imaging microscopy. Our group offers an outstanding and unique scientific setting with lot of individual freedom and possibilities for individual development as well as a vibrant working environment.

We would like to actively increase the proportion of female scientists in the Max Planck Society and the University of Göttingen and therefore particularly welcome applications from female students. We are also committed to employing more disabled persons and especially encourage them to apply.

Your application should include a cover letter, detailed CV and relevant certificates. Only full applications that are send as a single pdf file with the subject “PhD Student - MitoCRISTAE” to the provided email address will be considered. Closing date for applications: 31.7.2020. Do not hesitate to contact us if you have any further questions regarding the project and position.

Important note: successful applicants must be able to come to Göttingen (Germany) for a personal interview.

Please send inquiries and applications to

Prof. Stefan Jakobs – www.mitoweb.de
AG Struktur und Dynamik der Mitochondrien
Am Fassberg 11
37077 Göttingen
T +49 (0)551 201-2531
Email: jakobs-lab@gwdg.de
Twitter: @JakobsLab
Methoden: Biochemistry
Molecular Biology
Super resolution microscopy
Electron microscopy
Mass Spectrometry
Anfangsdatum: 1. August 2020
Geschätzte Dauer: 3 Years
Bezahlung: TVL_E13 (65%)
Papers:
Sonstiges:

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