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Archiv-Übersicht     Angebot Nr. 13932

Angebotsdatum: 22. Juli 2020
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Physiologie
Titel des Themas: Understanding right heart hypertrophy and right heart failure

Institut: International Giessen Graduate Center for Life Sciences (GGL)
Frau Faiqa Hossain
Leihgesterner Weg 52
35392 Giessen
Tel.:    Fax.:
Bundesland: Hessen
Homepage: http://www.uni-giessen.de/ggl-application
E-Mail Kontakt: mail

Beschreibung: One PhD position to support our current studies on right heart failure. The position should be filled as soon as possible.
Right heart failure develops in mammalians as a long-term adaptation to systemic pressure overload or pulmonary hypertension. Unlike the well understood adaptation of the left ventricle, right heart failure differs from this process leading to the requirement of specific treatment strategies that are not fully developed. In a project funded by the German Research Foundation, we investigate the molecular and cellular characteristics of right heart hypertrophy and its transition to right heart failure. The successful applicant will be embedded in this project and will support this project by molecular and cellular analysis in vitro and in vivo. Specific techniques required include the isolation and functional characterization of adult rat ventricular cardiomyocytes.
We offer an interdisciplinary and structured international PhD program (GGL).
We are seeking high qualified, enthusiastic students holding a M.Sc. or equivalent degree with a suitable background in life sciences. Applicants must be proficient in English. Prior knowledge of the German language is desired but does not constitute a requirement for your application to be considered.
The research group is embedded in the collaborative research center 1213 "Pulmonary Hypertension and Cor Pulmonale". The speciality of the group and its focus is on cellular and molecular mechanisms contributing to heart failure, more specific in the context of the project right heart failure. The research group is world wide leading in cultivation of terminal differentiated cardiomyocytes from left and right heart samples and their functional and molecular charactization.
We expect some experiences with cell cultivation and a high motivation to work on appropriate animal models alllowing to charactize the transition of right heart hypertrophy to heart failure. The successfull applicant should be team-orietented and have a good education in molecular biology.

Methoden: -Isolation and functional characterization of adult rat ventricular cardiomyocytes.
-Experiences with cell cultivation.
-Good education in molecular biology.
Anfangsdatum: 22. Juli 2020
Geschätzte Dauer: 3 years
Bezahlung: German federal public service scale TV-H (65% E13)
Sonstiges: For more details and instructions on how to apply please visit: https://www.uni-giessen.de/ggl-application