Zur Startseite von DrArbeit.de,
der deutschlandweiten Stellenbörse für Diplomarbeiten und Doktorarbeiten


Lupe2

Archiv - Stellenangebot

 

Dies ist ein Angebot aus der Datenbank von DrArbeit.de

Um die Datenbank komfortabel nach weiteren Angeboten durchsuchen zu können, klicken Sie einfach oben oder hier.

 
Archiv-Übersicht     Angebot Nr. 13938

Angebotsdatum: 13. Juli 2020
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Mikrobiologie
Titel des Themas: Investigation of the mechanism leading to establishment of persistent viral infection

Institut: Department of Molecular Medicine II
Adresse:
Dr. rer. nat. Haifeng Xu
Universitätsstraße 1
40225 Duesseldorf
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage:
E-Mail Kontakt: mail

Beschreibung: We are looking for a highly motivated candidate, interested in studying anti-viral immune mechanisms leading to either effective viral clearance or viral persistence using the lymphocytic choriomeningitis virus (LCMV) model system. The project aims to unravel how LCMV breaks the host immunity to set up a chronic infection. Techniques such as reverse genetic, flow cytometry, immunofluorescent microscopy etc., will be applied. Consequently, you will gain experience across a broad range of immunology and virology concepts and assays.

Qualification:
The candidate should have a Master degree in Biology, immunology, virology or a related filed. The candidate should be highly self-motivated, team-oriented, and should have a good knowledge in immunology and or virology.

Contact
Please send your application:
• Curriculum Vitae (including your work experience, publications).
• Cover letter (including the research area of interest and your motivation).
• Contact information for 2 referees.


To:
Dr. rer. nat. Haifeng Xu
xuh@hhu.de


Selected publications:

• Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A. CD8+ T cells induce cachexia during chronic viral infection. Nat Immunol. 2019 May 20. doi: 10.1038/s41590-019-0397-y.

• Xu HC, Huang J, Pandyra AA, Lang E, Zhuang Y, Thöns C, Timm J, Häussinger D, Colonna M, Cantor H, Lang KS, Lang PA. Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection. Cell Rep. 2017 Nov 28;21(9):2528-2540. doi: 10.1016/j.celrep.2017.11.001.

• Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M, Lang KS, Lang PA. Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection. J Virol. 2015 May;89(9):4748-59.

• Xu HC, Grusdat M, Pandyra AA, Polz R, Huang J, Sharma P, Deenen R, Köhrer K, Rahbar R, Diefenbach A, Gibbert K, Löhning M, Höcker L, Waibler Z, Häussinger D, Mak TW, Ohashi PS, Lang KS, Lang PA. Type I interferon protects antiviral CD8(+) T cells from NK cell cytotoxicity. Immunity. 2014 Jun 19;40(6):949-60.
Methoden:
Anfangsdatum: 13. Juli 2020
Geschätzte Dauer: 3 years
Bezahlung:
Papers:
Sonstiges:

Archiv-Übersicht