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Archiv-Übersicht     Angebot Nr. 13960

Angebotsdatum: 30. Juli 2020
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Humanmedizin > Orthopädie
Titel des Themas: Controlling inflammation and degeneration of cartilage in post-traumatic osteoarthritis

Institut: UNIVERSITY OF FREIBURG MEDICAL CENTER
Adresse:
PD Melanie Hart
Engesserstraße 4
79108 Freiburg
Tel.: +49 761 270 26102   Fax.:
Bundesland: Baden-Württemberg
Homepage: http://www.gerninfreiburg.de
E-Mail Kontakt: mail

Beschreibung: Post-traumatic osteoarthritis (PTOA) is a chronic, progressive disorder of the joints such as the knee, hip, and ankle that develops after trauma and affects people of all ages. It can lead to cartilage and bone damage and, ultimately, joint destruction, causing pain and even disability. The pathogenesis of PTOA is not fully understood but recent studies show that inflammation occurring immediately after joint injury plays a key role in its onset. My group uses inflammatory models of PTOA to investigate the use of biomaterials that release anti-inflammatory molecules with the aim of controlling the inflammatory response in PTOA and preventing PTOA.

This project focuses on developing basic design principles for steering anti-inflammatory pathways, keeping a potential clinical application for cartilage replacement or regeneration in mind.

Within this scheme we can offer various subprojects for a thesis project.
The project will be fully supervised to ensure success of your thesis project.

Interested students should send an e-mail with your CV, transcripts, letter of recommendations and timeline (start and end date) to:

PD Dr. Melanie Hart:
melanie.lynn.hart@uniklinik-freiburg.de
G.E.R.N. Engesserstraße 4, 79108 Freiburg, Germany
TEL: +49 761 270-26102
www.gerninfreiburg.de
Methoden: You will be trained in the following possible methods:

• Production of biomaterials
• Isolation and handling of human
chondrocytes and cartilage tissue from
knee and hip replacement surgeries
• Application of biomechanical forces
to post-traumatic events
• Droplet Digital PCR (ddPCR)
• ELISA
• Microscopic imaging of cells or tissues
• Live-dead assays
• Immunofluorescence
• Quantitative analysis of cellular
morphology
• Statistical analyses
• Training in English and German
Anfangsdatum: 19. Oktober 2020
Geschätzte Dauer: up to 1 year
Bezahlung: 0
Papers:
Sonstiges: There may be some flexibility with the starting date.

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