Zur Startseite von DrArbeit.de,
der deutschlandweiten Stellenbörse für Diplomarbeiten und Doktorarbeiten


Lupe2

Archiv - Stellenangebot

 

Dies ist ein Angebot aus der Datenbank von DrArbeit.de

Um die Datenbank komfortabel nach weiteren Angeboten durchsuchen zu können, klicken Sie einfach oben oder hier.

 
Archiv-Übersicht     Angebot Nr. 13998

Angebotsdatum: 7. September 2020
Art der Stelle: Doktorarbeit
Fachgebiet: Chemie > Biochemie
Titel des Themas: Guided tissue regeneration through patterned hydrogels with controlled biophysical and biochemical properties

Institut: Max Planck Institute of Colloids and Interfaces
Adresse:
Dr. rer. nat. Amaia Cipitria
Am Mühlenberg 1
14476 Potsdam
Tel.: +49 331 567-9452   Fax.:
Bundesland: Brandenburg
Homepage: http://www.mpikg.mpg.de/5861592/extracellular-matrix-in-disease-and-regeneration
E-Mail Kontakt: mail

Beschreibung: In our group “Extracellular Matrix in Disease and Regeneration” at the Max Planck Institute of Colloids and Interfaces we investigate the role of the biophysical microenvironment, in particular the physicochemical properties of tissues, extracellular matrix and collective of cells, in controlling tissue regeneration and cancer-related disease.

Healing processes are characterized by dynamic microenvironments, where local and temporal control of physicochemical cues orchestrate tissue self-organization. Alginate hydrogels can mimic such microenvironments and allow spatial control of hydrogel stiffness, degradability and presentation of polymer-bound biomolecules (1, 2). We hypothesize that matrix spatial patterning of biophysical and biochemical cues modulate cell metabolic activity and proliferation, soft and mineralized tissue organization and crosstalk with immune molecules. We aim to use engineered 3D matrices with tunable biophysical and biochemical, in combination with a minimally invasive in vivo model, to test this hypothesis and thereby improve our understanding of physiological bone regeneration and pathological alterations.
Methoden: We are looking for a doctoral researcher with a background in bioengineering, biotechnology, biochemistry or similar. He/she will work on synthesis and characterization of hydrogels with tunable biophysical and biochemical properties, cell culture, histology/immunohistochemistry and imaging.
Anfangsdatum: 7. September 2020
Geschätzte Dauer: 3-4 Jahre
Bezahlung: Ja
Papers: 1. A. Lueckgen, D.S. Garske, A.E. Ellinghaus, D.J. Mooney, G.N. Duda, A. Cipitria, “Dual alginate crosslinking for local patterning of biophysical and biochemical properties””, Acta Biomaterialia, 2020, in press (doi.org/10.1016/j.actbio.2020.07.047).

2. A. Lueckgen, D.S. Garske, A.E. Ellinghaus, D.J. Mooney, G.N. Duda, A. Cipitria, “Enzymatically-degradable alginate hydrogels promote cell spreading and in vivo tissue infiltration”, Biomaterials, 2019, 217:119294.
Sonstiges: In collaboration with Prof. Fratzl @BM_MPICI @MpiciPotsdam, Prof. Mooney @wyssinstitute and colleagues at Berlin-Brandenburg School for Regenerative Therapies @ChariteBerlin

Application through:
https://bsrt.cloud.opencampus.net/call2020/project12

Archiv-Übersicht