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Archiv-Übersicht     Angebot Nr. 14014

Angebotsdatum: 18. September 2020
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Zellbiologie
Titel des Themas: PhD student position in proteome homeostasis

Institut: Center for Molecular Medicine Cologne (CMMC)
Frau Débora B. Trentini Schmidt
Robert-Koch-Str. 21
50931 Köln
Tel.: +49 221 478-42566   Fax.:
Bundesland: Nordrhein-Westfalen
Homepage: http:// https://jobs-uk-koeln.de/index.php?ac=jobad&id=1685
E-Mail Kontakt: mail

Beschreibung: As a modern maximum-care hospital with a capacity of approximately 1,540 beds, the University Hospital of Cologne is dedicated to the practice of innovative academic medical excellence. At the Faculty of Medicine 1.800 scientists are engaged in research, ranging from basic sciences to clinical application, as well as teaching and health care. Together with the University Hospital Cologne the faculty maintains 58 clinics, research institutes and centres. 3.400 students study in this dynamic and innovative environment. The Faculty of Medicine and the University Hospital Cologne are embedded in the scientifically highly active Rhine region. They have strong contacts to and alliances with the surrounding universities and non-university research institutions guaranteeing scientific excellence in research and teaching.

The CMMC invites applications for the research group “Protein quality control and stress response” of Dr. Debora B. Trentini Schmidt for:
PhD Student (65%)

The Center for Molecular Medicine Cologne (CMMC) is a multidisciplinary center at the University of Cologne providing a forum that brings together physician scientists with basic researchers from the Faculty of Medicine and the Faculty of Mathematics and Natural Sciences to perform competitive basic, disease-oriented research. The mission of the CMMC is to advance the understanding of the underlying molecular and cellular mechanisms as a prelude to improving prevention, diagnosis and treatment of many common health problems. For further information, please visit CMMC (https://www.cmmc-uni-koeln.de/home).

Research overview:
Protein folding represents an intricate process requiring proteins to navigate a complex energy landscape, putting them at risk for adopting non-native structures. Misfolded proteins are not only dysfunctional, but they can also coalesce into potentially toxic aggregates that are considered a hallmark of many neurodegenerative diseases. Therefore, cells are equipped with a complex and adaptive network of factors ensuring protein synthesis, folding, conformational maintenance, and degradation. The central interest of our laboratory is to understand how protein quality control pathways distinguish functional proteins from aberrant species, and how they make the decision between repair and degradation. We are also interested in understanding how these pathways are regulated upon proteotoxic stress and certain disease situations. We use a combination of genetic, biochemical, chemical-biology, and mass spectrometry-based approaches to mechanistically characterize protein quality control pathways in human cells, as well as to evaluate cellular consequences upon their failure.
Please visit CMMC -Trentini-Lab (https://www.trentini-lab.cmmc-uni-koeln.de/) to learn more about the group’s interests and ongoing research.

We are looking for:
• Highly qualified and motivated students holding a M.Sc. or equivalent degree in biochemistry, cell/molecular biology, biomedicine or related field;
• Enthusiasm for protein biochemistry and mechanism-driven basic research;
• Experience in biochemistry and/or molecular biology;
• Conceptual understanding of Proteomics and related technologies is desired, but not mandatory;
• High level of motivation, commitment, endurance and positivity;
• Ability and willingness to work in a collaborative team;
• Excellent communication in English (written and speech);

We offer:
• Close support and method training by the PI;
• Modern laboratories and infrastructure for training and research;
• Access to core facilities offering state-of-the-art technologies (see https://www.cmmc-uni-koeln.de/core-facilities/overview and https://www.cecad.uni-koeln.de/research/core-facilities/)
• A thriving research campus, with many internationally-recognized research institutes in direct reach: Cologne Center for Genomics, Max Planck Institute for Metabolism Research, Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD), and the Max-Planck Institute for Biology of Ageing;
• A structured graduate program held in English, fostering career development through scientific and soft skills training;
• Salary according to the German salary scale TV-L, following the Act of Academic Fixed-Term Contract (Wissenschaftszeitvertragsgesetz – WissZeitVG). The initial contract is limited to 3 years, with possibility of extension.
Applications from female candidates are expressly welcome and will be given priority in the event of equal suitability, competence and professional performance.
People with disabilities are welcome to apply and will be treated preferentially in the event of equal suitability and qualification.
The position is suitable for staffing with part-time employees.

Send application to
Have we awakened your interest? Please submit your application (including a detailed CV, two references and a brief statement of research interests) online (http:// https://jobs-uk-koeln.de/index.php?ac=jobad&id=1685) until 25th of October.

For further information and informal enquiries, please contact:
Dr. Debora B. Trentini Schmidt
Anfangsdatum: 18. September 2020
Geschätzte Dauer: 3-4 years
Bezahlung: according to the German salary scale TV-L (65%)