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Archiv-Übersicht     Angebot Nr. 14023

Angebotsdatum: 2. Oktober 2020
Art der Stelle: Doktorarbeit
Fachgebiet: Biologie > Molekularbiologie
Titel des Themas: PhD Position (Medical Biochemistry & Molecular Biology): Lipid Droplet Biogenesis and Function

Institut: Universität des Saarlandes, Medizinische Biochemie & Molekularbiogie / Präklinisches Zentrum für Molekulare Signalverarbeitung (PZMS)
Adresse:
Prof. Bianca Schrul
Kirrbergerstr. 100
66421 Homburg
Tel.:    Fax.:
Bundesland: Saarland
Homepage: http://www.pzms.uni-saarland.de/index.php/junior-prof-bianca-schrul
E-Mail Kontakt: mail

Beschreibung: We are looking for a highly motivated scientist with a diploma / masters degree in natural sciences to join our young and growing team as a PhD student. The position is immediately available at the Department of Medical Biochemistry & Molecular Biology / Center for Molecular Signaling (PZMS) of the Saarland University in the research group of Jun.-Prof. Bianca Schrul.

Our group is interested in the biogenesis and function of lipid droplets. These subcellular organelles dynamically balance the influx, storage and consumption of neutral lipids in nearly all cells of our body and are therefore central hubs in lipid metabolism. Lipid droplets are implicated in a range of human pathologies including hallmark diseases of our modern society such as obesity, diabetes, hepatic steatosis and cardiovascular disorders. However, the molecular mechanisms underlying lipid droplet biogenesis and function as well as pathologic aberrations in these processes remain largely unknown.

Projects in our lab address the following questions:

What are the molecular mechanisms underlying protein targeting and insertion into the limiting membrane of lipid droplets?

How is lipid droplet biogenesis from the endoplasmic reticulum membrane regulated?

How do lipid droplets communicate with other lipid metabolizing organelles to adapt to metabolic changes?

We employ a range of biochemical and cell biological techniques including in vitro reconstitution experiments, protein-interaction studies, organelle / protein isolations, CRISPR/Cas9 genome editing, RNA interference, quantitative proteomics, lipidomics analyses as well as advanced fluorescence and electron microscopy. Furthermore, we have established interdisciplinary collaborations with theoretical and experimental physicists.

Further information can be found on our website: http://www.pzms.uni-saarland.de/index.php/junior-prof-bianca-schrul

We are looking for a highly motivated scientist with the following qualifications:

- Excellent Diploma / M.Sc. degree in Biochemistry, Molecular Biology or a related discipline
- Strong interest in basic Biochemical and Cell Biological Research
- Interest in learning Molecular Dynamics (MD) Simulations would be a plus
- Excellent communication skills
- Fluent English (oral and written) is essential
- German language skills are desired

Please send your application including a short cover letter stating your research interests, a CV, degree certificates and contacts for two references via e-mail to Jun.-Prof. Dr. Bianca Schrul.
Methoden:
Anfangsdatum: 1. November 2020
Geschätzte Dauer: 3 years
Bezahlung:
Papers: Dhiman R., Caesar S., Thiam AR., Schrul B. (2020)
Mechanisms of protein targeting to lipid droplets: A unified cell biological and biophysical perspective.
Semin Cell Dev Biol. 2020 Mar 20. pii: S1084-9521(18)30299-4. doi: 10.1016/j.semcdb.2020.03.004, PMID: 32201131

Schrul B. and Schliebs W. (2018)
Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19.
Biol Chem. 2018 Jun 27;399(7):741-749, PMID: 29500918

Schrul B. and Kopito R.R. (2016)
Peroxin-Dependent Targeting of a Lipid Droplet-Destined Membrane Protein to ER Subdomains.
Nat Cell Biol. 2016 Jul;18(7):740-51, PMID: 27295553
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