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Archiv-Übersicht     Angebot Nr. 14026

Angebotsdatum: 6. Oktober 2020
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Biologie
Titel des Themas: Synaptic Trafficking Mechanisms underlying Neuronal Plasticity, Learning and Memory

Institut: Institute for Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH
Prof. Matthias Kneussel
Falkenried 94
20251 Hamburg
Tel.:    Fax.:
Bundesland: Hamburg
Homepage: http://www.kneussel.de
E-Mail Kontakt: mail

Beschreibung: Synaptic plasticity, learning and memory relies on the precise regulation of trafficking mechanisms that deliver, remove and recycle synaptic proteins from axo-dendritic contacts. We have characterized motor proteins, transport factors and regulators of the actin- and microtubule cytoskeleton to investigate their contribution in the adaptation of synaptic strength. Future projects aim to understand how external triggers such as neuronal activity changes, inflammation and infection alter synapse function in neuronal development and neuronal disease.
Methoden: We combine molecular and biochemical techniques with live cell microscopy, electrophysiology and mouse genetics to study neuron and brain function. These basic research approaches will be extended with iPSC-derived neurons from human patients.

Anfangsdatum: 6. Oktober 2020
Geschätzte Dauer: 3 years
Bezahlung: E13/65%
Papers: Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, Schindelin H (2019) Elucidating the molecular basis for inhibitory neurotransmission regulation by Artemisinins. Neuron 101:673-689 e611.

Gromova KV, Muhia M, Rothammer N, Gee, CE, Thies E, Schaefer I, Kress S, Kilimann MW, Shevchuk O, Oertner TG, Kneussel M (2018) Neurobeachin and the Kinesin KIF21B are critical for endocytic recycling of NMDA receptors and regulate social behavior. Cell Reports 23:2705–2717.

Heisler FF, Pechmann Y, Wieser I, Altmeppen HC, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M (2018) Muskelin coordinates PrPC 1 lysosome versus exosome targeting and impacts prion disease progression. Neuron 99:1155-1169.e9

Ghiretti AE, Thies E, Tokito MK, Lin T, Ostap EM, Kneussel M, Holzbaur ELF (2016) Activity-dependent regulation of distinct transport and cytoskeletal remodeling functions of the dendritic kinesin KIF21B. Neuron 92:857-872.

Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T (2016) Branch-specific microtubule destabilization mediates axon branch loss during neuromuscular synapse elimination. Neuron 92:845-856.

Hausrat, TJ, Muhia, M, Gerrow, K, Thomas, P, Hirdes, W, Tsukita, S, Heisler, FF, Herich, L, Dubroqua, S, Breiden, P, Feldon, J, Schwarz, JR, Yee, BK, Smart, TG, Triller, A, Kneussel, M (2015) Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. Nature Communications 6:6872.

Heisler FF, Lee HK, Gromova KV, Pechmann Y, Schurek B, Ruschkies L, Schroeder M, Schweizer M, Kneussel M (2014) GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites. Proc Natl Acad Sci USA 111:5030-5035.

Kneussel M, Wagner W (2013) Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics. Nature Reviews Neuroscience 14:233-247.

Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Bruck W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA (2012) TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. Nature Medicine 18:1805-1811.

Heisler FF, Loebrich S, Pechmann Y, Maier N, Zivkovich AR, Tokito M, Hausrat TJ, Schweizer M, Bähring R, Holzbaur EL, Schmitz D, Kneussel M (2011) Muskelin regulates actin filamentand microtubule-based GABA-AR transport in neurons. Neuron 70:66-8
Sonstiges: We are seeking for a highly motivated PhD student to address how changes in the neuronal excitation-inhibition balance and/or inflammatory triggers affect synaptic trafficking and physiology. The Institute for Molecular Neurobiology at the ZMNH is part of the University Medical Center Hamburg-Eppendorf. It offers a stimulating and challenging scientific environment. The PhD student will be part of the DFG-funded research unit FOR 2419 and will take part in the ZMNH PhD program. We offer equal opportunities independent of age, sex, origin or disability.

Applications should include a cover letter stating research interests and previous experience, a CV and the contact information of two referees. Please send your application to Prof. Dr. Matthias Kneussel (matthias.kneussel@zmnh.uni-hamburg.de).