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Archiv-Übersicht     Angebot Nr. 14041

Angebotsdatum: 14. Oktober 2020
Art der Stelle: Doktorarbeit / Diplomarbeit
Fachgebiet: Biologie > Genetik
Titel des Themas: Proteostasis Mechanisms in Aging and Disease

Institut: Institut für Genetik
Adresse:
Prof. Thorsten Hoppe
Albertus-Magnus-Platz
50931 Köln
Tel.:    Fax.:
Bundesland: Nordrhein-Westfalen
Homepage:
E-Mail Kontakt: mail

Beschreibung: Protein homeostasis (proteostasis) is achieved via conserved quality control pathways that support correct protein folding and activity.
Unfortunately, the proteostasis network has a limited capacity and its impairment triggers aggregation of damaged proteins that deteriorate
organismal viability. Protein aggregation in the human brain is central to neurodegeneration causing intelectual and motor deficits. By manipulating the proteostasis machinery, our team was able to delay the aging process and extend the lifespan in the nematode model C. elegans.

YOUR PROFILE

» Master of Science (e.g. Biology)

» Enthusiastic and highly motivated

» Interested in fundamental protein quality control mechanisms and aging research

» Good communication skills, fluency in English and the ability for teamwork

» Experience with genetic model organisms and/or molecular genetics
Methoden: YOUR TASKS

» Studying proteostasis with in vitro and in vivo biochemical assays and determine the response mechanisms upon neuronal stimulation, proteotoxic stress conditions and aging

» Combining state of the art genetic screening, biochemical and in vivo imaging techniques

» Studying the regulation of proteostasis networks in C. elegans and human cell models

» Defining proteostasis networks essential for stress resistance and tissue functionality
Anfangsdatum: 1. Januar 2021
Geschätzte Dauer: 3 Jahre
Bezahlung: remuneration group TV-L 13
Papers:
Sonstiges: Please send your application with proof of the required qualifications by email (in one pdf-file) to: Prof. Dr. Thorsten Hoppe (thorsten.hoppe@uni-koeln.de) with the reference number Wiss2009-19. The application deadline is 15 November 2020.

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