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Archiv-Übersicht     Angebot Nr. 14099

Angebotsdatum: 22. März 2021
Art der Stelle: Doktorarbeit
Fachgebiet: Chemie > Physikalische Chemie
Titel des Themas: protein folding dynamics studied by time-resolved infrared spectroscopy

Institut: Physikalische Chemie
Prof. Karin Hauser
Universitätsstr. 10
78457 Konstanz
Tel.:    Fax.:
Bundesland: Baden-Württemberg
Homepage: http://www.biophysik.uni-konstanz.de
E-Mail Kontakt: mail

Beschreibung: The project is dedicated to study protein folding dynamics by time-resolved infrared (IR) spectroscopy. In particular, a home-built IR spectrometer with a laser-excited temperature-jump will be used to monitor sub-millisecond structural dynamics. Focus of the project is the understanding of molecular mechanisms in the stabilization of protein structures. Model peptides with novel site-specific infrared probes will be applied to analyze structural dynamics on the basis of individual amino acids, thereby exploring backbone and side-chain dynamics separately.
Methoden: time-resolved IR-spectroscopy;
quantum cascade lasers;
laser-excited temperature-jump;
sub-millisecond dynamics:
peptide models and design;
site-specific IR probes:
Anfangsdatum: 1. Mai 2021
Geschätzte Dauer: 3-4 Jahre
Papers: Scheerer, D., Chi, H., McElheny, D., Keiderling, T., Hauser, K. "Enhanced sensitivity to local dynamics in peptides by use of temperature-jump IR-spectroscopy and isotope labeling", Chem Eur J, 2020, 26, 3524-3534

Siu, H., Heck, B., Kovermann, M., Hauser, K. "Template-assisted design of monomeric polyQ models to unravel the unique role of glutamine side chains in disease-related aggregation", Chemical Science 2020, DOI: 10.1039/D0SC05299J

Popp, A., Scheerer, D., Heck, B., Hauser, K. "Biomolecular dynamics studied with IR-spectroscopy using quantum cascade lasers combined with nanosecond perturbation techniques", Spectrochim Acta A Mol Biomol Spectrosc, 2017, 181, 192–199
Sonstiges: We are looking for a highly motivated student who has successfully completed a master in (bio)physics or chemistry. The ideal candidate should have experience in spectroscopic techniques or laser spectroscopy or optics. Interest in biophysical research and interdisciplinary work is expected. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.

The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available.

Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Karin.Hauser@uni-konstanz.de.