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Archiv-Übersicht     Angebot Nr. 14100

Angebotsdatum: 2. Dezember 2020
Art der Stelle: Doktorarbeit
Fachgebiet: Chemie > Angewandte Makromolekulare Chemie
Titel des Themas: molecular interactions studied by infrared spectroscopy

Institut: Physikalische Chemie
Prof. Karin Hauser
Universitätsstr. 10
78457 Konstanz
Tel.:    Fax.:
Bundesland: Baden-Württemberg
Homepage: http://www.biophysik.uni-konstanz.de
E-Mail Kontakt: mail

Beschreibung: The project is dedicated to study molecular interaction mechanisms by infrared spectroscopy. We established an ATR-FTIR spectroscopic approach to study aggregation pathways of polyglutamine (polyQ) proteins by the controlled initiation of the aggregation process facilitating the structural characterization of intermediates in dependence of time. Expanded glutamine repeats are found in many neurodegenerative diseases, but molecular mechanisms leading to disease-related aggregates or preventing aggregation are not well understood. Focus of the project is the further development of the infrared spectroscopic approach and the analysis of molecular interactions between polyQ repeats and chaperones. PolyQ aggregation kinetics and pathways shall be analyzed in the presence of chaperones to get insights into molecular mechanisms of chaperone function.
Methoden: ATR-FTIR spectroscopy;
protein immobilization;
reaction-induced difference spectroscopy
Anfangsdatum: 1. Januar 2021
Geschätzte Dauer: 3-4 Jahre
Papers: Yushchenko, T., Deuerling, E., Hauser, K. "Insights into the aggregation mechanism of polyQ proteins with different glutamine repeat lengths", Biophys. J., 2018, 114, 1847-1857

Krüger, A., Bürkle, A., Hauser, K.*, Mangerich, A.* "Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy", Nat. Commun 2020, 11, 2174
Sonstiges: We are looking for a highly motivated student who has successfully completed a master in (bio)chemistry, (bio)physics, life science or biology. The ideal candidate should have a strong interest in spectroscopy and biophysical research. Further requirements are the ability to work independently and in a team, as well as good English language proficiency.

The position is integrated in the Collaborative Research Center 969 “Chemical and Biological Principles of Cellular Proteostasis” (A2) and immediately available.

Interested candidates should send their application (including motivation letter, CV, brief summary of master thesis, certificates) by e-mail to Karin.Hauser@uni-konstanz.de.