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Archiv-Übersicht     Angebot Nr. 14147

Angebotsdatum: 10. Februar 2021
Art der Stelle: Doktorarbeit
Fachgebiet: Physik > Biophysik
Titel des Themas: Computational Systems Biology

Institut: University of Freiburg, Center for Data Analysis and Modelling
Dr. rer. nat. Christian Fleck
Ernst-Zermelo-Strasse 1
79104 Freiburg
Tel.:    Fax.:
Bundesland: Baden-Württemberg
Homepage: http://cygentig.ethz.ch
E-Mail Kontakt: mail

Beschreibung: Currently, building of new tissues requires inefficient, manual manipulation that is time-consuming, labor-intensive and introduces high variability in the finished products. Relieving this limitation has implications for both health and wealth. Control of tissue growth means control of biological self-organization and is one of the great challenges in modern regenerative medicine, biotechnology and synthetic biology. This Ph.D. project will be embedded in an international research consortium (CyGenTiG) with the aim to control tissue growth through optogenetics. CyGenTiG is an international collaborative scientific program to develop techniques for controlling living cells, including human cells, with light. Compared to drugs or physical interventions, light has huge advantages: it can be shone only when it is needed, it dose can be controlled with high accuracy, and it can be switched off the instant its work is done.

The successful Ph.D. candidate will develop multi-scale models for cellular tissue using and extending the agent-based simulation platform PhysiCell. In close collaboration with partners from the consortium he/she has to analyze experimental data and develop the corresponding models for in silico experiments.
Methoden: Mathematical Modelling, Statistical Analysis, Multi-Scale Modelling, C++ programming, Ordinary Differential Equations, Partial Differential Equations, Cellular Biology, Molecular Biology
Anfangsdatum: 1. April 2021
Geschätzte Dauer: 3 Years
Bezahlung: TV-L E13 50 %