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| Angebotsdatum: |
15. September 2021
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| Art der Stelle: |
Doktorarbeit / Diplomarbeit |
| Fachgebiet: |
Chemie > Organische Chemie
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| Titel des Themas: |
peptide synthesis & drug development of anticancer/antibacterial drugs
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| Institut: |
Institut für Chemie
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| Adresse: |
| Prof. Roderich Süssmuth |
| Strasse des 17. Juni 124, TC2 |
| 10623 Berlin |
| Tel.: 030 314 24205 Fax.:
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| Bundesland: Berlin |
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| Homepage: |
http://https://www.biochemie.tu-berlin.de/index.html
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| E-Mail Kontakt: |
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| Beschreibung: |
The Biological Chemistry group at the Department of Chemistry, Technische Universität Berlin, Germany, is seeking to fill several positions for
PhD and Postdoctoral Research Associates
in the area of drug development by peptide synthesis and medicinal chemistry (Target: anticancer and antibacterial drugs drug profiling) – some projects are part of a collaboration with the bioindustry / pharma industry.
Research topics: Research will focus on the organic synthesis of drug molecules and their bioactivity profiling, experience in bioassays, multidimensional NMR spectroscopy, mass spectrometry are appreciated. Beyond lab work, leadership will be required to manage the project via progress reports to project sponsors to advise students.
Prerequisites: Suitable candidates for this position
• hold a Master or PhD degree in Organic Chemistry/Biochemistry/Pharmacy or Biological Chemistry/Life Sciences
• have had hands-on experience with organic synthesis, peptide synthesis, additionally optional proteomics, biochemistry and protein chemistry
• are self-driven individuals with proven success in and executing independent scientific research
• have displayed a scientific publication history
• have outstanding verbal and written
communication skills
• are energetic, ambitious team players.
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| Methoden: |
organic synthesis, peptide synthesis (solid support, automated peptide synthesis), ESI-MS, HPLC, 2D NMR spectroscopy, assay development, medicinal chemistry, pharmacokinetic & pharmacodynamics studies.
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| Anfangsdatum: |
1. November 2021 |
| Geschätzte Dauer: |
3,5 years
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| Bezahlung: |
Entgeltgruppe 13 TV-L Berliner Hochschulen
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| Papers: |
Representative papers are:
Siegert, M.J., Knittel, C.H., Süssmuth*, R.D. "A Convergent Total Synthesis of the Death Cap Toxin alpha-Amanitin." Angew. Chem. Int. Ed. 2020, 59(14), 5500-5504
Wiebach, V., Mainz, A., Schnegotzki, R., Siegert, M.J., Hügelland, M., Pliszka, N., Süssmuth*, R.D. "An amphipathic alpha-helix guides maturation of the ribosomally-synthesized lipolanthines." Angew. Chem. Int. Ed. 2020, 59(38), 16777-16785
Rostock, L., Driller, R., Grätz, S., Kerwat, D., von Eckardstein, L., Petras, D., Kunert, M., Alings, C., Schmitt, F.-J., Friedrich, T., Wahl, M.C., Loll, B., Mainz, A., Süssmuth*, R.D. "Molecular insights into antibiotic resistance - how a binding protein traps albicidin." Nat. Commun. 2018, 9(1), 3095
Yao, G., Joswig, J.O., Keller, B.G., Süssmuth*, R.D. "Total synthesis of the death cap toxin Phalloidin - atropoisomer-selectivity explained by molecular-dynamics simulations." Chemistry. 2019, 25(34), 8030-8034
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| Sonstiges: |
Interested individuals should send their CV, a list of publications and a list of three references to
Prof. Dr. Roderich Süssmuth at suessmuth@chem.tu-berlin.de.
More information on the Biological Chemistry group at the Department of Chemistry at
https://www.biochemie.tu-berlin.de/
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