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Archiv-Übersicht     Angebot Nr. 14338

Angebotsdatum: 28. Juli 2021
Art der Stelle: Doktorarbeit
Fachgebiet: Humanmedizin > Pathologie
Titel des Themas: Research Fellow/PhD Student position in translational cancer research

Institut: Institut für Pathologie
Prof. Monika Hämmerle
Magdeburger Straße 14
06112 Halle (Saale)
Tel.:    Fax.:
Homepage: http://https://www.medizin.uni-halle.de/forschung/nachwuchsgruppen/nwg-haemmerle
E-Mail Kontakt: mail

Beschreibung: The Martin-Luther-University Halle-Wittenberg, Medical Faculty, Institute of Pathology, Section for Experimental Pathology (Head: Jun.-Prof. Dr. Monika Hämmerle), offers a position for a Research Fellow (m-f-d)beginning 01.09.2021 for a period of 3 years in a part-time appointment (65 %).

The salary will be in accordance with salary class 13 TV-L, pending classification based on individual

• Characterizing of pro-tumorigenic and pro-metastatic signaling pathways in solid tumors focusing on the
tumor microenvironment
• Identification of new target molecules for innovate cancer treatment
• Opportunity for further academic qualification (PhD) is given

• Master degree in the fields of life sciences (biochemistry, biology, or related)
• Basic skills in cell biology, biochemical and molecular biology techniques
• Experience with laboratory animals (mice) including Felasa B certificate would be of advantage
• Basic understanding of RNA biology, tumor biology and/or immunology
• Good/excellent command of English, both spoken and written
• Innovative, independent and reliable working behavior paired with high intrinsic motivation
• Proactive team player with a readiness of mind and a strong passion for science

This position is part of the consortium ‘Non autonomous Mechanisms in Cancer’ (NAUTICA), a newly established research unit funded by the Medical Faculty. This consortium consists of a unique and strongly interdisciplinary network of clinical scientist and basic researchers and enables excellent interdisciplinary training within a doctoral thesis.
For more information: https://www.medizin.uni-halle.de/forschung/nachwuchsgruppen/nwg-haemmerle

The Martin-Luther-University Halle-Wittenberg gives priority to applications from severely disabled candidates with equivalent qualifications. Women are particularly encouraged to apply.

Please submit your application with the Registration Number 7-138/21-H until 02/08/2021 to the Medical Faculty of the Martin-Luther-University Halle-Wittenberg, Institute of Pathology, Jun.Prof. Dr. Monika Hämmerle, Kurt Mothes-Str. 3 a, 06120 Halle (Saale) or an electronic application (as a single PDF file) to Jun.Prof. Dr. Monika
Hämmerle: monika.haemmerle@uk-halle.de
Methoden: • 2D and 3D co-culture assays of tumor cells with immune cells and fibroblasts as well as platelets
• In vivo experiments
• Multispectral imaging
Anfangsdatum: 1. September 2021
Geschätzte Dauer: 3 years
Papers: Neu CT, Gutschner T, Haemmerle M (2020). Post-Transcriptional Expression Control in Platelet Biogenesis and Function. Int J Mol Sci, 21(20):7614.

Glaß M, Dorn A, Hüttelmaier S, Haemmerle M*, Gutschner T* (2020). Comprehensive Analysis of LincRNAs in Classical and Basal-Like Subtypes of Pancreatic Cancer. Cancers (Basel), 12(8):2077.

Dorn A, Glass M, Neu CT, Heydel B, Hüttelmaier S, Gutschner T*, Haemmerle M* (2020). LINC00261 Is Differentially Expressed in Pancreatic Cancer Subtypes and Regulates a Pro-Epithelial Cell Identity. Cancers (Basel), 12(5):1227.

Gutschner T, Richtig G, Haemmerle M, Pichler M (2018). From biomarkers to therapeutic targets-the promises and perils of long non-coding RNAs in cancer. Cancer Metastasis Rev, 37(1):83-105.

Haemmerle M, Stone RL, Menter DG, et al. (2018). The Platelet Lifeline to Cancer: Challenges and Opportunities. Cancer Cell, 33(6):965-983.

Haemmerle M, Taylor ML, Gutschner T, et al. (2017). Platelets reduce anoikis and promote metastasis by activating YAP1 signaling. Nat Commun, 8(1):310.

Cho MS, Noh K, Haemmerle M, et al. (2017). Role of ADP receptors on platelets in the growth of ovarian cancer. Blood, 130(10):1235-1242.

Haemmerle M, Bottsford-Miller J, Pradeep S, et al. (2016). FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal. J Clin Invest, 126(5):1885-96.

Gutschner T, Hämmerle M, Pazaitis N et al. (2014). The Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important pro-tumorigenic factor in hepatocellular carcinoma. Hepatology, 59(5):1900-11.

Hämmerle M, Gutschner T et al. (2013). Post-transcriptional destabilization of the liver-specific long non-coding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1). Hepatology, 58 (5):1703–1712.